SPAG6 Antibody

中文名稱：

SPAG6兔多克隆抗體
貨號：

CSB-PA022467LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of U251 cells with CSB-PA022467LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SPAG6 Polyclonal antibody
Uniprot No.：

O75602
基因名：

SPAG6
別名：

axoneme central apparatus protein antibody; DKFZp434I153 antibody; MGC26276 antibody; PF16 antibody; PF16 protein homolog antibody; Protein PF16 homolog antibody; Repro SA 1 antibody; Repro-SA-1 antibody; SPAG6 antibody; SPAG6_HUMAN antibody; Sperm associated antigen 6 antibody; Sperm flagellar protein antibody; Sperm-associated antigen 6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sperm-associated antigen 6 protein (343-428AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SPAG6 Antibody (CSB-PA022467LA01HU)，的標記方式是Non-conjugated。對于SPAG6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022467LB01HU	SPAG6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022467LC01HU	SPAG6 Antibody, FITC conjugated
Biotin	CSB-PA022467LD01HU	SPAG6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
基因功能參考文獻：
1. These results demonstrate that SPAG6 silencing induces PTEN expression to regulate apoptosis though the PI3K/AKT pathway, indicating that SPAG6 may be a potential therapeutic target for myelodysplastic syndromes. PMID: 29749435
2. SPAG6 and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells. PMID: 28093071
3. Study demonstrates that SPAG6 may regulate apoptosis through the TRAIL signal pathway by inhibiting the expression of FADD and the interactions between FADD and the TRAIL death receptors. PMID: 28393201
4. studies demonstrate a role for Spag6 in the pathogenesis of OM in mice, possibly through its role in the regulation of cilia/basal body polarity through the PCP-dependent mechanisms in the middle ear and Eustachian tubes. PMID: 25393619
5. These findings demonstrate that SPAG6 might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase proteins and p53, suggesting that SPAG6 may be a potential therapeutic target. PMID: 25405588
6. SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia. PMID: 20668334
7. Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein. PMID: 12391165
顯示更多

收起更多
亞細胞定位：

Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme.
組織特異性：

Highly expressed in testis.
數據庫鏈接：

HGNC: 11215

OMIM: 605730

KEGG: hsa:9576

STRING: 9606.ENSP00000365811

UniGene: Hs.655170

Most popular with customers

YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human