SOX18 Antibody
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中文名稱：SOX18兔多克隆抗體
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貨號：CSB-PA186645
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規格：￥1100
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圖片：
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, mouse heart tissue, K562 cells, Jurkat cells, Primary antibody: CSB-PA186645(SOX18 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：SOX18
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別名：HLTS antibody; SOX 18 antibody; Sox18 antibody; SOX18_HUMAN antibody; SRY (sex determining region Y) box 18 antibody; SRY box 18 antibody; Transcription factor SOX 18 antibody; Transcription factor SOX-18 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human SOX18
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.
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基因功能參考文獻：
- results suggest that SOX18 is overexpressed in Osteosaroma (OS) and plays an important role in proliferation, apoptosis, migration and invasion of OS cells, and may provide a novel and promising thera-peutic strategy for OS. PMID: 29266413
- The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction PMID: 29749465
- A novel mutation in the SOX18 gene identified in a patient with hypotrichosis-lymphedema-telangiectasia syndrome. PMID: 29307792
- Results showed that on the contrary of the mRNA level, the protein levels of SOX18 were higher in lung adenocarcinoma (AC) cases compared to levels noted in the non-malignant lung tissues (NMLTs). The disparity between the mRNA and protein levels of the SOX18 transcription factor was caused by miR-7a and miR-24-3p, although the mechanism through which lung cancer cells downregulate miRNA molecule levels is still unclear. PMID: 29115529
- miR-7-5p targeted SOX18 to inhibit gp130/JAK2/STAT3 signaling pathway to exert its suppressing role in Pancreatic ductal adenocarcinoma PMID: 29408481
- Nuclear expression of SOX18 was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC cancer cells PMID: 27127146
- SOX18 plays a significant role in promoting the growth of pancreatic ductal adenocarcinoma, and might serve as a promising target for PDAC therapy PMID: 27663663
- Study reports SOX18 as novel risk gene for Neural tube defects (NTDs) but findings also suggest that SOX18 hypomethylation and increased expression must interplay with other environmental and (epi)genetic factors that are causative for NTDs. PMID: 27757173
- SOX18 was overexpressed in prostate cancer.SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7. PMID: 27922675
- the results of this study suggest that knockdown of SOX18 inhibits breast cancer cell growth and invasion, possibly by downregulating downstream oncogenic proteins, providing novel insights into the development of breast cancer therapy through targeting of SOX18. PMID: 27108946
- miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination PMID: 27666488
- The downregulation of SOX18 was found to significantly inhibit cell adhesion and invasion. PMID: 26573263
- NKD2 inhibits SOX18 and MMP-2,7,9 expression and suppresses BGC823 cell xenograft growth. NKD2 methylation may serve as a poor prognostic and chemo-sensitive marker in human gastric cancer. NKD2 impedes gastric cancer metastasis by inhibiting SOX18. PMID: 26396173
- GLI1 and GLI2, but not GLI3 are involved in the regulation of SOX18 gene expression in cervical carcinoma cell lines. PMID: 26588701
- we demonstrated that upregulation of SOX18 was associated with a poor outcome in hepatocellular carcinoma patients PMID: 26151573
- The genetic finding of a pathogenic SOX18 mutation enabled the diagnosis of the rare hypotrichosis-lymphedema-telangiectasia syndrome in our patient. PMID: 26148450
- A new, autosomal dominant condition combining hypotrichosis-lymphedema-telangiectasia syndrome with renal defects is associated with a novel truncating mutation in the SOX18 gene. PMID: 24697860
- SOX18 may be involved in the progression of Non small cell lung cancer. PMID: 25310193
- SOX18wt has potent trans-activation proper- ties, while SOX18DN displayed dominant-negative effect. PMID: 24460943
- Data suggest that SOX18 transcription factor expression may serve as a marker for a poor prognosis in invasive ductal breast carcinoma. PMID: 24065215
- The repression of Sox18 and its target genes may lead to altered formation of vessels in inflamed settings. PMID: 24269235
- of the 679 gastric cancer cases, 177 (26.1%) were positive for SOX 18 expression in their tumor stroma, and the frequencies of both lymphovascular invasion and lymph node metastases were higher in the SOX 18 positive than in the negative group. PMID: 21796627
- The identification of MMP7 as a direct SOX18 target gene as well as other potential candidates including guidance molecules provides a molecular basis for the proposed function of this transcription factor in the regulation of vessel formation. PMID: 22292085
- Heterogeneous methylation in the promoter region of SOX18 was associated with cancer progression in non-small cell lung cancer. PMID: 22018271
- Mutations in SOX18 underlie recessive and dominat forms of hypertrichosis-lymphedema- telangiectasis/ PMID: 12740761
- SOX18 is involved in vascular cell growth and this transcription factor may play a role in atherosclerosis PMID: 16179596
- Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton. PMID: 16882943
- an obligatory role for SOX-18 in the regulation of claudin-5 gene expression in an endothelial-specific and cell density-dependent manner is established PMID: 18065521
- Transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region. PMID: 18496767
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相關疾病：Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS); Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome (HLTRS)
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亞細胞定位：Nucleus.
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組織特異性：Detected in heart, lung, placenta, skeletal muscle, liver, kidney, spleen, prostate, ovary, msosmall intestine and colon.
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