SOSTDC1 Antibody, FITC conjugated
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中文名稱：SOSTDC1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA022416EC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SOSTDC1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：CDA019 antibody; DKFZp564D206 antibody; Ectodermal BMP inhibitor antibody; Ectodin antibody; sclerostin domain containing 1 antibody; Sclerostin domain containing protein 1 antibody; Sclerostin domain-containing protein 1 antibody; SOSD1_HUMAN antibody; Sostdc1 antibody; USAG-1 antibody; USAG1 antibody; Uterine sensitization associated gene 1 protein antibody; Uterine sensitization-associated gene 1 protein antibody; Wise antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Sclerostin domain-containing protein 1 protein (24-206AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
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基因功能參考文獻：
- findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. PMID: 28551845
- Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. PMID: 26378658
- Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
- Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer PMID: 25858146
- Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1. PMID: 24190897
- DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer. PMID: 23830730
- SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer. PMID: 21113658
- Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women. PMID: 21221677
- genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors. PMID: 21080955
- Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
- USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist. PMID: 15020244
- This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors. PMID: 18032587
- Loss of SOSTDC1 gene is associated with Wilms tumor. PMID: 19760604
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亞細胞定位：Secreted.
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蛋白家族：Sclerostin family
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組織特異性：Highly expressed in kidney and weakly in lung.
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數據庫鏈接：
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