SNX17 Antibody

中文名稱：

SNX17兔多克隆抗體
貨號：

CSB-PA614877LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue
All lanes: SNX17 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 53, 50 kDa
Observed band size: 53 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA614877LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA614877LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SNX17 Polyclonal antibody
Uniprot No.：

Q15036
基因名：

SNX17
別名：

Similar to a putative C elegans gene encoded in cosmid F17H10 antibody; Snx17 antibody; SNX17_HUMAN antibody; Sorting nexin 17 antibody; Sorting nexin-17 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Sorting nexin-17 protein (280-457AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SNX17 Antibody (CSB-PA614877LA01HU)，的標記方式是Non-conjugated。對于SNX17 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA614877LB01HU	SNX17 Antibody, HRP conjugated	ELISA
FITC	CSB-PA614877LC01HU	SNX17 Antibody, FITC conjugated
Biotin	CSB-PA614877LD01HU	SNX17 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
基因功能參考文獻：
1. HPV-16 L2 recruitment of SNX17 occurs prior to capsid disassembly. PMID: 28475030
2. The double knockdown of SNX17 and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein. PMID: 26202251
3. SNX17 plays a role in the maintenance of normal surface levels of activating receptors and integrins to permit optimum T cell activation at the immune synapse. PMID: 25825439
4. Data indicate that the major binding site for binding of sorting nexin 17 (SNX17) is confined to the NPXF2 motif in cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1). PMID: 25059659
5. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling. PMID: 24705369
6. The authors demonstrate that SNX17 is essential for infection with all papillomavirus types analyzed, indicating an evolutionarily highly conserved virus entry mechanism. PMID: 23115288
7. depletion of SNX17 in HeLa cells resulted in lysosomal degradation of multiple members of the integrin family of extracellular matrix recep-tors. PMID: 22492727
8. expression level of SNX17 may regulate the lysosomal degradation, at least for P-selectin, by suppressing its entry into the inner vesicles of the multi-vesicular bodies (MVBs) PMID: 15769472
9. Snx 17 binds to a motif in the low-density lipoprotein (LDL) receptor-related protein (LRP) tail distinct from the endocytosis signals and promotes LRP sorting to the recycling pathway in the early endosomes. PMID: 16052210
10. SNX17 has a role in the indicated KRIT1 function in cell adhesion processes by integrin signaling PMID: 16712798
11. SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes PMID: 18276590
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亞細胞定位：

Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Sorting nexin family
數據庫鏈接：

HGNC: 14979

OMIM: 605963

KEGG: hsa:9784

STRING: 9606.ENSP00000233575

UniGene: Hs.278569

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