SNAP91 Antibody

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SNAP91 Polyclonal antibody
Uniprot No.：

O60641
基因名：

SNAP91
別名：

SNAP91 antibody; KIAA0656Clathrin coat assembly protein AP180 antibody; 91 kDa synaptosomal-associated protein antibody; Clathrin coat-associated protein AP180 antibody; Phosphoprotein F1-20 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Clathrin coat assembly protein AP180 protein (628-907AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.
基因功能參考文獻：
1. intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
2. To sustain efficient neurotransmission and synaptic vesicle formation, AP180 and VAMP2 are required. PMID: 26412491
3. unique mechanism of SNARE motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 and CALM as cargo-specific adaptors for synaptobrevin endocytosis PMID: 21808019
4. AP180 is significantly decreased in the hippocampus of Alzheimer's disease patients and in hippocampal neurons of transgenic mice. PMID: 20847448
5. AP180 had an overall expression similar to synaptophysin, the immunoreactivity for the two proteins did not always co-localize. PMID: 12493563
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亞細胞定位：

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

PICALM/SNAP91 family
數據庫鏈接：

HGNC: 14986

OMIM: 607923

KEGG: hsa:9892

STRING: 9606.ENSP00000358708

UniGene: Hs.368046

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