SMS Antibody

中文名稱：

SMS兔多克隆抗體
貨號：

CSB-PA021854LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA021854LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA021854LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA021854LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SMS Polyclonal antibody
Uniprot No.：

P52788
基因名：

SMS
別名：

MRSR antibody; SMS antibody; Snyder Robinson X linked mental retardation syndrome antibody; Spermidine aminopropyltransferase antibody; Spermine synthase antibody; SPMSY antibody; SpS antibody; SPSY_HUMAN antibody; SRS antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Spermine synthase protein (16-191AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SMS Antibody (CSB-PA021854LA01HU)，的標記方式是Non-conjugated。對于SMS Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA021854LB01HU	SMS Antibody, HRP conjugated	ELISA
FITC	CSB-PA021854LC01HU	SMS Antibody, FITC conjugated
Biotin	CSB-PA021854LD01HU	SMS Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
基因功能參考文獻：
1. Missense mutations causing Snyder-Robinson Syndrome resulting in dysfunctional spermine synthase cause the destabilization of the protein. PMID: 26761001
2. Results show that p.Y328C, a missense mutation in SMS is responsible for the patients having a mild form of Snyder-Robinson syndrome. PMID: 23696453
3. Studied human spermine synthase activity by engineered mutations. PMID: 23468611
4. This observation is used to demonstrate, computationally and experimentally, that a particular condition, Snyder-Robinson syndrome caused by the G56S spermine synthase mutation, might be ameliorated by small molecule binding. PMID: 23408511
5. spermine synthase activity and the resulting elevation of the spermine:spermidine ratio does not alter susceptibility to tumor development initiated by c-Ha-Ras mutation or Apc loss PMID: 22258329
6. the mutability of spermine synthase PMID: 21647366
7. Mutations in the spermine synthase have been shown to be responsible for an X-linked intellectual disability condition known as Snyder-Robinson syndrome. PMID: 21318891
8. each gene was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1). PMID: 21152090
9. the genetic and epigenetic factors examined in this study show little influence on the expression level of SMS in suicide completers. PMID: 20059804
10. Study reports the identification of a novel mutation at a highly conserved residue within the N-terminal region of spermine synthase (SMS) in a second family with Snyder-Robinson X-linked mental retardation syndrome. PMID: 18550699
11. A missense mutation, p. V132G, in the X-linked SMS gene causes Snyder-Robinson syndrome. PMID: 19206178
12. Data suggest that disruption of spermine synthase function may negatively affect regional brain volumes that subserve cognitive and motor abilities. PMID: 19277733
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相關疾病：

X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR)
蛋白家族：

Spermidine/spermine synthase family
數據庫鏈接：

HGNC: 11123

OMIM: 300105

KEGG: hsa:6611

STRING: 9606.ENSP00000385746

UniGene: Hs.724874

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