SMARCD1 Antibody
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中文名稱：SMARCD1兔多克隆抗體
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貨號：CSB-PA021808GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：SMARCD1
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別名：60 kDa BRG-1/Brm-associated factor subunit A antibody; 60 kDa BRG1/Brm associated factor subunit A antibody; BAF60A antibody; BRG1 associated factor 60A antibody; BRG1-associated factor 60A antibody; Chromatin remodeling complex BAF60A subunit antibody; CRACD1 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 60A antibody; Rsc6p antibody; SMARCD1 antibody; SMRD1 antibody; SMRD1_HUMAN antibody; SWI/SNF complex 60 kDa subunit A antibody; SWI/SNF complex 60 kDa subunit antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin d1 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 antibody; Swp73 like protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human SMARCD1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.
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基因功能參考文獻：
- miR-223 targets the expression of SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinomas. PMID: 29079174
- miR-7 expression reduced SMARCD1 protein expression in lung cancer cell lines. PMID: 26542803
- the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with bone mineral density in white women, as conducted. PMID: 25396734
- SMARCD1/BAF60a is an androgen receptor cofactor that modulates TMPRSS2 expression PMID: 19762545
- In addition to previously identified BAF250, BAF60a may provide another critical and direct link between nuclear receptors and the BRG1 complex that is required for promoter recruitment and subsequent chromatin remodeling PMID: 12917342
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亞細胞定位：Nucleus.
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蛋白家族：SMARCD family
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組織特異性：Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta.
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數據庫鏈接：
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