SLC7A7 Antibody, FITC conjugated

說明書

中文名稱：

SLC7A7兔多克隆抗體, FITC偶聯
貨號：

CSB-PA892349LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC7A7 Polyclonal antibody
Uniprot No.：

Q9UM01
基因名：

SLC7A7
別名：

LAT3 antibody; LPI antibody; Monocyte amino acid permease 2 antibody; MOP-2 antibody; MOP2 antibody; SLC7A 7 antibody; Slc7a7 antibody; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 7 antibody; Solute carrier family 7 member 7 antibody; y(+)L type amino acid transporter 1 antibody; y(+)L-type amino acid transporter 1 antibody; Y+L amino acid transporter 1 antibody; y+LAT-1 antibody; Y+LAT1 antibody; YLAT1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Y+L amino acid transporter 1 protein (325-382AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
基因功能參考文獻：
1. SLC7A7 overexpression decreased the apoptosis rate, increased the proportion of cells in the G1 phase, decreased the proportion of G2 cells, and significantly increased cell migration and invasion and increased intracellular arginine would activate mTOR, and induce apoptosis in SLC7A7 knockdown Jurkat cells. PMID: 30025393
2. Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia. PMID: 29499643
3. At present, 51 kinds of SLC7A7 gene mutations causing lysinuric protein intolerance have been found worldwide, including insert (C.1384-1385 ins ACTA), delete (C.1185-1188 del TTCT) and point mutations (P.R410X, P.Y457X, P.R 468X, P.L124p, etc).3, 4 In our cases, there were two heterozygous mutations in the SLC7A7 gene of the two sisters: C.1387 del C and IVS4+1C>T, which has never been reported worldwide. PMID: 29058386
4. The study reports a significant association between SLC7A7 rs12436190 and the risk of glioma in a Chinese population. PMID: 28510245
5. the 1471 delTTCT mutation was identified in exon 9 in the homozygous state for all Tunisian patients with lysinuric protein Intolerance; The 1471 deITTCT mutation seems to be a common mutation of Tunisian population PMID: 26882824
6. heteromerization of y+LAT1 and 4F2hc within the cell is not disrupted by any of the tested LPI mutations PMID: 23940088
7. SLC7A7 genetic variants are associated with increase risk for glioma in a Chinese population. PMID: 23975734
8. SLC7A7 plays a critical role in glioblastoma carcinogenesis and overexpression of SLC7A7 is correlated with worse outcomes in patients PMID: 23408368
9. SLC7A7/y+LAT1 mutations lead to a defective phenotype of macrophages resulting in lysinuric Protein Intolerance. PMID: 22325938
10. during differentiation of human monocytes from peripheral blood, SLC7A7 mRNA and system y(+)L activity are increased PMID: 21586674
11. novel SLC7A7 mutations in patients with lysinuric protein intolerance PMID: 12402335
12. expression levels and putative 5' promoter elements of the SLC7A7 gene PMID: 12589791
13. putative multiheteromeric structure of both [4F2hc/y(+)LAT-1] and [4F2hc/y(+)LAT-2], and the interference between y(+)LAT-1 and y(+)LAT-2 proteins may have a role in the pathogenesis of lysinuric protein intolerance PMID: 15756301
14. mutations of the SLC7A7 gene may have a role in lysinuric protein intolerance PMID: 15776427
15. identified a novel alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of SLC7A7 gene expression PMID: 17196863
16. Mutation in the SLC7A7 gene is associated with lysinuric protein intolerance PMID: 17666782
17. A review of the current knowledge of SLC7A7 mutations and their role in LPI pathogenesis. PMID: 17764084
18. results suggest genomic rearrangement of SLC7A7 play more important role in lysinuric protein intolerance than has been reported; 3' region AluY repeat could be a recombination hot spot as it is involved in 38% of SLC7A7 rearranged chromosomes described PMID: 18716612
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相關疾病：

Lysinuric protein intolerance (LPI)
亞細胞定位：

Basolateral cell membrane; Multi-pass membrane protein.
蛋白家族：

Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
組織特異性：

Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, ret
數據庫鏈接：

HGNC: 11065

OMIM: 222700

KEGG: hsa:9056

STRING: 9606.ENSP00000285850

UniGene: Hs.513147

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