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中文名稱：SLC6A6兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA021704LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLC6A6 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：MGC10619 antibody; MGC131729 antibody; OTTHUMP00000208177 antibody; OTTHUMP00000208180 antibody; SC6A6_HUMAN antibody; SLC6A6 antibody; Sodium- and chloride-dependent taurine transporter antibody; Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 antibody; Solute carrier family 6 member 6 antibody; TAUT antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Sodium- and chloride-dependent taurine transporter protein (1-49AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
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基因功能參考文獻：
- TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. PMID: 26955642
- CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy PMID: 26206726
- This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells. PMID: 25501278
- Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells. PMID: 24842606
- Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface. PMID: 24866236
- Taurine transporter is a novel pathological marker for stressed motor neurons in amyotrophic lateral sclerosis. PMID: 23180277
- Taurine transporter deficiency results in aberrant trophoblast turnover and fetal growth restriction. PMID: 23519128
- Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy. PMID: 23392873
- Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes. PMID: 23392892
- TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients. PMID: 21739148
- TNF-alpha-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells. PMID: 12062416
- TauT is involved with p53 in renal development and apoptosis. PMID: 12163498
- regulation by WT1 PMID: 12681485
- nitric oxide plays an important role in downregulating microvillous plasma membrane taurine transporter activity in intrauterine growth restriction PMID: 15166008
- The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. PMID: 15225620
- TAUT activity in TNF-alpha-treated Caco-2 cells suggests that up-regulation was associated with an increase in the amount of TAUT. PMID: 15630186
- reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region PMID: 15907840
- taurine cotransporter is regulated by oxidative stress and overexpression of aldose reductase and high glucose impair this response PMID: 16356117
- Greater system beta activity in fetal platelets compared with T lymphocytes is the result of relatively greater TAUT mRNA and protein expression. PMID: 16956961
- Report taurine transporter activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
- This study demonstrates the functional coexpression of TauT along with the PAT1 transporter (SLC36A1) at the apical membrane of the intestinal epithelium. PMID: 19074966
- critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway PMID: 19423693
- Glucose reduced taurine transporter (TauT) mRNA and protein in a dose-dependent manner. PMID: 19602579
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
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組織特異性：Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.
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數據庫鏈接：
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