SLC52A2 Antibody

中文名稱：

SLC52A2兔多克隆抗體
貨號：

CSB-PA881008LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA881008LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA881008LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC52A2 Polyclonal antibody
Uniprot No.：

Q9HAB3
基因名：

SLC52A2
別名：

SLC52A2 antibody; GPR172A antibody; PAR1 antibody; RFT3 antibody; Solute carrier family 52 antibody; riboflavin transporter antibody; member 2 antibody; Porcine endogenous retrovirus A receptor 1 antibody; PERV-A receptor 1 antibody; Protein GPR172A antibody; Riboflavin transporter 3 antibody; hRFT3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Solute carrier family 52, riboflavin transporter, member 2 protein (217-276AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SLC52A2 Antibody (CSB-PA881008LA01HU)，的標記方式是Non-conjugated。對于SLC52A2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA881008LB01HU	SLC52A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA881008LC01HU	SLC52A2 Antibody, FITC conjugated
Biotin	CSB-PA881008LD01HU	SLC52A2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4-hydroxybutyrate (Probable).; (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
基因功能參考文獻：
1. RFVT2 gene and protein expression levels were higher in DLD-1 and HT-29 compared to Caco2 cells. In tumor tissues of patients with CRC, RFVT2 gene expression levels were increased, while protein expression was reduced, with a small reduction in riboflavin amount. PMID: 29715086
2. This is the second report of the genotype-phenotype correlation between this syndrome named spinocerebellar ataxia with blindness and deafness type 2 (SCABD2) and SLC52A2 gene. PMID: 29287867
3. Eight mutations in SLC52a2 were associated with Brown-Vialetto-Van Laere syndrome. PMID: 29053833
4. A novel SLC52A2 mutation identified in a family with spinocerebellar ataxia with blindness and deafness. PMID: 26669662
5. This study showed that Auditory neuropathy in Brown-Vialetto-Van Laere syndrome due to riboflavin transporter RFVT2 deficiency and improved by riboflavin treatment. PMID: 26918385
6. These results strongly implicate a potential role for SLC52A2 in riboflavin uptake by milk-producing MECs, a critical step in the transfer of riboflavin into breast milk. PMID: 26791833
7. Mutations in SLC52A2 result in a recognizable phenotype distinct from Brown-Vialetto-Van-Laere syndrome. PMID: 24616084
8. We demonstrate that SLC52A2 mutations cause reduced riboflavin uptake and reduced riboflavin transporter protein expression PMID: 24253200
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相關疾病：

Brown-Vialetto-Van Laere syndrome 2 (BVVLS2)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Riboflavin transporter family
組織特異性：

Highly expressed in brain, fetal brain and salivary gland. Weakly expressed in other tissues.
數據庫鏈接：

HGNC: 30224

OMIM: 607882

KEGG: hsa:79581

STRING: 9606.ENSP00000333638

UniGene: Hs.6459

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