SLC52A1 Antibody

中文名稱：

SLC52A1兔多克隆抗體
貨號：

CSB-PA878904LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA878904LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA878904LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA878904LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC52A1 Polyclonal antibody
Uniprot No.：

Q9NWF4
基因名：

SLC52A1
別名：

FLJ10060 antibody; G protein coupled receptor 172B antibody; GPCR antibody; GPCR42 antibody; hRFT1 antibody; member 1 antibody; OTTHUMP00000125300 antibody; PAR2 antibody; PERV-A receptor 2 antibody; PERVA receptor 2 antibody; Porcine endogenous retrovirus A receptor 2 antibody; Protein GPR172B antibody; Putative G protein coupled receptor GPCR42 antibody; Riboflavin transporter 1 antibody; riboflavin transporter antibody; S52A1_HUMAN antibody; SLC52A1 antibody; Solute carrier family 52 antibody; Solute carrier family 52, riboflavin transporter, member 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Solute carrier family 52, riboflavin transporter, member 1 protein (212-279AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SLC52A1 Antibody (CSB-PA878904LA01HU)，的標記方式是Non-conjugated。對于SLC52A1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA878904LB01HU	SLC52A1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA878904LC01HU	SLC52A1 Antibody, FITC conjugated
Biotin	CSB-PA878904LD01HU	SLC52A1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.; (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
基因功能參考文獻：
1. We here report a case of transient MADD, caused by a heterozygous intronic variation, c.1134+11G>A, in the SLC52A1 gene encoding RFVT1. This variation creates a binding site for the splice inhibitory hnRNP A1 protein and causes exon 4 skipping. Riboflavin deficiency and maternal malnutrition during pregnancy might have been the determining factor in the outcome of this case. PMID: 29122468
2. In HT-29 cells, the RFVT1 protein level was drastically lower. In tumor tissues of patients with CRC, RFVT1 content was reduced at both protein and mRNA levels compared to normal mucosa. PMID: 29715086
3. results are the first to reveal the identity of the minimal SLC52A1 promoter and to establish an important role for Sp-1 in its activity PMID: 25284511
4. data suggest that MMND is a distinct clinical subgroup of childhood onset MND patients where the known genetic defects are so far negative. PMID: 24139842
5. summary of recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3 [review] PMID: 23506902
6. Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3. PMID: 23413253
7. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the PAR-2 expression in human villous trophoblast cells. PMID: 22702469
8. Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter. PMID: 18632736
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相關疾病：

Riboflavin deficiency (RBFVD)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Riboflavin transporter family
組織特異性：

Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues.
數據庫鏈接：

HGNC: 30225

OMIM: 607883

KEGG: hsa:55065

STRING: 9606.ENSP00000254853

UniGene: Hs.632247

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