SLC4A5 Antibody
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中文名稱(chēng)：SLC4A5兔多克隆抗體
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貨號(hào)：CSB-PA874837LA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: Hela whole cell lysate, U87 whole cell lysate
All lanes: SLC4A5 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 127, 125, 116, 109, 108, 114, 119 kDa
Observed band size: 127 kDa -
Immunofluorescence staining of HepG2 cells with CSB-PA874837LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) SLC4A5 Polyclonal antibody
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Uniprot No.：
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基因名：SLC4A5
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別名：Electrogenic sodium bicarbonate cotransporter 4 antibody; MGC129662 antibody; NBC4 antibody; NBCe2 antibody; S4A5_HUMAN antibody; SLC4A5 antibody; Solute carrier family 4 member 5 antibody; Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Electrogenic sodium bicarbonate cotransporter 4 protein (1071-1137AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁(yè)面中的產(chǎn)品，SLC4A5 Antibody (CSB-PA874837LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SLC4A5 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IF 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
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基因功能參考文獻(xiàn)：
- NBCe2 activity is stimulated by an increase in intracellular sodium and is hyper-responsive in hRPTCs carrying HV SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism PMID: 29642240
- NBCe2 could be important in proximal kidney tubule apical sodium and bicarbonate cotransport under high-salt conditions. PMID: 26447209
- we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron--{REVIEW} PMID: 26136555
- Data indicate that 2 SNPs in SLC4A5 (rs7571842 and rs10177833) showed highly significant results and large effects sizes. PMID: 22987918
- The additive effect of rs10177833 of SLC4A5 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153). PMID: 22764636
- Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5 PMID: 19384345
- Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). PMID: 12063394
- These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear. PMID: 16365189
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亞細(xì)胞定位：Apical cell membrane; Multi-pass membrane protein.
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蛋白家族：Anion exchanger (TC 2.A.31) family
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組織特異性：Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach a
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數(shù)據(jù)庫(kù)鏈接：
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