SLC41A1 Antibody
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中文名稱：SLC41A1兔多克隆抗體
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貨號：CSB-PA810274LA01HU
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規格：￥440
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圖片：
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IHC image of CSB-PA810274LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
Immunofluorescence staining of HepG2 cells with CSB-PA810274LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLC41A1 Polyclonal antibody
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Uniprot No.：
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基因名：SLC41A1
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別名：SLC41A1 antibody; Solute carrier family 41 member 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Solute carrier family 41 member 1 protein (1-96AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，SLC41A1 Antibody (CSB-PA810274LA01HU)，的標記方式是Non-conjugated。對于SLC41A1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC, IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:200-1:500 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain.
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基因功能參考文獻：
- Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. PMID: 28222767
- The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of Parkinson's Disease was replicated in our population. PMID: 27612022
- Authors performed direct DNA sequencing of the SLC41A1 gene in 100 early-onset PD cases. PMID: 26308152
- Na+-dependent Mg2+ efflux conducted by Na+/Mg2+ exchanger SLC41A1 is regulated by insulin. PMID: 26355001
- This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese Parkinson disease. PMID: 24661466
- SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas PMID: 23844728
- Binding partners of SLC41A1, were identified. PMID: 23823179
- Alanine350Valine substitution in Na/Mg(2) exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation. PMID: 23976986
- In normal human kidney tissue, endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary, consistent with the region of cystogenesis observed in nephronophthisis. PMID: 23661805
- Direct DNA sequencing of the SLC41A1 and RAB7L1 genes within the PARK16 locus in 205 Chinese Parkinson's disease patients shows no significant difference with controls. PMID: 21812739
- The human SLC41A1 gene encodes for the Na+/Mg(2)+ exchanger, the predominant Mg(2)+ efflux system. PMID: 22031603
- Results indicate that SLC41A1 proteins are a central component of Mg(2+) transport systems, and that their Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain. PMID: 21696366
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20683486
- Data report the identification and structural characterization of solute carrier family 41 member 1 (SLC41A1), a eukaryotic protein with homology to the bacterial MgtE family of potential Mg(2+) transporters. PMID: 12810078
- The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. PMID: 15713785
- SLC41A1 is a novel mammalian Mg2+ carrier PMID: 18367447
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：SLC41A transporter family
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組織特異性：Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
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數據庫鏈接：
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