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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
基因功能參考文獻:
there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function PMID: 27355203
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport. PMID: 27129276
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2. PMID: 26608079
Decreased placental mTOR activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR. PMID: 26374858
GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2. PMID: 26041779
Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression. PMID: 25653282
SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis. PMID: 23408887
SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows. PMID: 23728383
Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants. PMID: 22028413
findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA PMID: 21930789
Proteomic analysis of TAP-tag purified SNAT2 fusion proteins identified two novel SNAT2-interacting proteins that may potentially function in conjunction with SNAT2 transceptor to regulate signalling pathways influencing protein turnover and cell growth PMID: 21622135
Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. PMID: 20206993
SNAT2 amino acid response element, along with a nearby conserved CAAT box, has enhancer activity and it confers regulated transcription to a heterologous promoter PMID: 14623874
The synthesis of SNAT2 is required for the hypertonic stimulation of system A transport activity. PMID: 15581851
Up-regulation of SNAT2 is essential for the rapid restoration of cell volume after hypertonic stress. PMID: 15922329
Amino acid depletion was associated with an up-regulation of amino acid transport system A activity, largely mediated through an enhancement of SNAT2 expression at both the protein and mRNA level in BeWo cells. PMID: 16125834
deficient in the amino acid response pathway exhibited little or no induction of SNAT2 mRNA PMID: 16445384
The strong expression of Na(+)-coupled neutral amino acid transporter 2 in the somato-dendritic compartment and in non-neuronal elements that are integral parts of the blood-brain and brain-cerebrospinal fluid barrier. PMID: 16616430
SNAT2 expression can be modulated by specific signaling pathways in response to different stresses PMID: 16621798
Results suggest that cortisol may be involved in upregulation of system A (SNAT2)in the placenta to ensure sufficient amino acid supply to the developing fetus. PMID: 16621896
Therefore, we can speculate that such anion-conducting pathways are general features of Na+-transporting systems. PMID: 17237199
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed PMID: 18697751
Report SNAT2 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
analysis of a conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 PMID: 19589777
we have identified a novel regulatory pathway involving increased gene expression of the SNAT2 isoform mediated by a STAT-dependent pathway, which links IL-6 to increased activity of amino acid transporter system A PMID: 19741197
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亞細胞定位:
Cell membrane; Multi-pass membrane protein.
蛋白家族:
Amino acid/polyamine transporter 2 family
組織特異性:
Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein