SLC35A1 Antibody
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中文名稱：SLC35A1兔多克隆抗體
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貨號(hào)：CSB-PA021583ESR1HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA021583ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) SLC35A1 Polyclonal antibody
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Uniprot No.：
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基因名：SLC35A1
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別名：CMP-SA-Tr antibody; CMP-Sia-Tr antibody; CMP-sialic acid transporter antibody; S35A1_HUMAN antibody; Slc35a1 antibody; Solute carrier family 35 member A1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human CMP-sialic acid transporter protein (1-100AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP.
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基因功能參考文獻(xiàn)：
- We performed exome sequencing on an individual with a profound neurological presentation and identified rare compound heterozygous mutations, p.Thr156Arg and p.Glu196Lys, in the CMP-sialic acid transporter, SLC35A1. Patient primary fibroblasts and serum showed a considerable decrease in the amount of N- and O-glycans terminating in sialic acid PMID: 28856833
- the SLC35A1 generates additional isoforms through alternative splicing. PMID: 27387429
- SLC35A1-deficient cells lack of alpha-dystroglycan O-mannosylation, ligand binding and incorporation of sialic acids. PMID: 25552652
- We confirm an autosomal recessive, generalized sialylation defect due to mutations in SLC35A1 PMID: 23873973
- substrate binding specificity PMID: 12682060
- this defect is a new type of congenital disorder of glycosylation (CDG) of type IIf affecting the transport of CMP-sialic acid into the Golgi apparatus. PMID: 15576474
- this study, we introduced two critical genes encoding human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter into tobacco suspension-cultured cell to pave a route for sialic biosynthetic pathway. PMID: 16343442
- CMP-sialic acid transporter is localized in the medial-trans Golgi PMID: 16923816
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相關(guān)疾?。?/div>Congenital disorder of glycosylation 2F (CDG2F)亞細(xì)胞定位：Golgi apparatus membrane; Multi-pass membrane protein.蛋白家族：Nucleotide-sugar transporter family, SLC35A subfamily數(shù)據(jù)庫鏈接：
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