SLC30A2 Antibody
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中文名稱：SLC30A2兔多克隆抗體
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貨號：CSB-PA060119
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：SLC30A2
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別名：SLC30A2; ZNT2; Zinc transporter 2; ZnT-2; Solute carrier family 30 member 2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human ZnT-2.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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基因功能參考文獻：
- ZNT2 was localized on the cell surface of both human and mouse beta-cells, suggesting a role of ZNT2 in direct export of zinc out of the beta-cell PMID: 29372370
- Article highlights the importance of early diagnosis of SLC30A2/ZnT2 variants in order to supplement zinc-deficient infants in real-time, thus preventing TNZD morbidity and enhancing newborn health. [Review] PMID: 28665435
- many SLC30A2/ZnT2 mutations cause or potentially cause transient neonatal zinc deficiency, as shown in three cases of Japanese infants PMID: 27304099
- findings establish that some heterozygous loss of function ZnT2 mutations disrupt zinc binding and zinc permeation, thereby suggesting a haploinsufficiency state for the unaffected WT ZnT2 allele in Transient Neonatal Zinc Deficiency PMID: 27137936
- Our study indicates that SLC30A2 variants are common in this population, dysregulate Zn management and can lead to breast cell dysfunction. PMID: 26293594
- Human ZnT2 expression is regulated by MTF-1. PMID: 25618524
- PRL-R attenuation post-transcriptionally increased ZnT2 abundance and redistributed intracellular Zn pools into lysosomes and mitochondria. PMID: 24333596
- Results indicated that -697G>T and 1031A>G polymorphisms in the SLC30A2 gene may be associated with low-milk-zinc in Chinese breastfeeding women. PMID: 22364884
- inactivating ZnT-2 mutations are an underlying basis of TNZD and provide the first evidence for the dominant inheritance of heterozygous ZnT-2 mutations via negative dominance due to homodimer formation. PMID: 22733820
- Pancreatic release of zinc by acinar cells is through the secretory process and apical membrane and involves transporter ZnT2 PMID: 21462106
- a mutation in SLC30A2 (ZnT-2) may have a role in transient neonatal zinc deficiency PMID: 17065149
- ZnT2 can facilitate vesicular zinc accumulation independently of AP-3 function, and validate the M1 fibroblastoid line as a human cell culture system amenable to the study of vesicular zinc regulation. PMID: 17349999
- hZnT-2 was not detectable in leukocytes. PMID: 17971500
- The localization and function of each ZnT2 isoform, was examined. PMID: 19496757
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相關疾病：Zinc deficiency, transient neonatal (TNZD)
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亞細胞定位：Vacuole membrane; Multi-pass membrane protein.; [Isoform 2]: Lysosome membrane.
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蛋白家族：Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
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數據庫鏈接：
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