SLC2A4 Antibody, HRP conjugated

說明書

中文名稱：

SLC2A4兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA021557EB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SLC2A4 Polyclonal antibody
Uniprot No.：

P14672
基因名：

SLC2A4
別名：

insulin-responsive antibody; Glucose transporter GLUT 4 antibody; Glucose transporter type 4 antibody; Glucose transporter type 4 insulin responsive antibody; GLUT 4 antibody; GLUT-4 antibody; GLUT4 antibody; GTR4_HUMAN antibody; Insulin responsive glucose transporter type 4 antibody; kug antibody; SLC 2A4 antibody; SLC2A4 antibody; solute carrier family 2 (facilitated glucose transporter) member 4 antibody; Solute carrier family 2 member 4 antibody; Solute carrier family 2, facilitated glucose transporter member 4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 4 protein (223-287AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
基因功能參考文獻：
1. Higher expression of GLUT-4 is associated with Oral Epithelial Dysplasia compared to Oral Squamous Cell Carcinoma. PMID: 30049187
2. Adipose tissue sirtuin 1 was related to insulin sensitivity. The relationship was still present after controlling for BMI, however, it disappeared after controlling for adipose tissue SLC2A4. Muscle sirtuin 1 was not related to insulin sensitivity. PMID: 29417372
3. Results showed that GLUT4 translocation is regulated by TBC1D15 affecting glucose uptake. PMID: 30316925
4. This review will summarize the effects of phytochemicals and their action on insulin signaling pathways accelerating GLUT4 translocation based on the current literature. PMID: 29382104
5. Cell-autonomous adiposity results from increased cell surface GLUT4 due to ankyrin-B deficiency in humans and mice. PMID: 29133412
6. The authors show that insulin-stimulated Glut4-mediated glucose uptake requires PDPK1 phosphorylation of the kinase domain but not mTORC2 phosphorylation of the hydrophobic domain. Nonetheless, an intact hydrophobic domain is required for Glut4-mediated glucose uptake. PMID: 28589878
7. rs5435 was not associated with T1D in the Euro-Brazilian population. PMID: 28973736
8. Three polymorphisms (rs2654185, rs5415, and rs5417) in SLC2A4 were positively correlated with hip circumference and the rs2654185 locus was also positively associated with thigh circumference. Consumption of n-3 polyunsaturated fatty acids modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes. PMID: 27467133
9. increased GLUT4 expression in oral squamous cell carcinoma patients was significantly associated with a poor overall survival (OS, P = 0.035) and recurrence-free survival (RFS, P = 0.001). Furthermore, the ectopic overexpression of GLUT4 in cell lines with low endogenous GLUT4 expression resulted in a significant increase in migratory ability both in vitro and in vivo PMID: 28061796
10. our study has found that BMI, hypertension, myometrial invasion, pathological type, and Glut4 positive expression might be prognostic factors of EC [Endometrial cancer ] PMID: 26437953
11. Our work highlights the convenience and efficiency of this novel pH-sensitive fluorescent probe and reveals the new biological activity of staurosporine as an agonist for GLUT4 translocation and as an effective insulin additive analogue. PMID: 27769857
12. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization. PMID: 27226625
13. This review focuses on recent advances on the role of these signaling pathways and transcription factors involved in the regulation of CD36 and GLUT4. PMID: 27403883
14. These results suggest that the initial event caused by overnutrition may be oxidative stress, which produces insulin resistance, at least in part, via carbonylation and oxidation-induced inactivation of GLUT4. PMID: 26355033
15. A single bout of exercise elicited similar GLUT4 translocation in skeletal muscle of PCOS and Controls. The absence of impairment in GLUT4 translocation suggests that PCOS patients with obesity and insulin resistance may benefit from exercise training. PMID: 26373822
16. SLC2A4 gene expression level was slightly lower within type 2 diabetic patients in both type of tissues. Furthermore, the negative correlation between SLC2A4 gene expression level in visceral adipose tissue and BMI has been noticed PMID: 26529385
17. GIV directly and constitutively binds the exocyst complex subunit Exo-70 and also associates with GLUT4-storage vesicles (GSVs) exclusively upon insulin stimulation. PMID: 26514725
18. Data suggest that down-regulation of GLUT4 expression in white/beige/brown adipocytes is associated with impaired glucose uptake/metabolism, impaired adipogenesis, and insulin resistance. [REVIEW] PMID: 25703677
19. Study of the molecular mechanisms of GLUT4 regulation in adipocytes. PMID: 24656589
20. These results indicate that T2DM patients may have a high level miR-199a that reduce GLUT4 expression and contribute to the insulin resistance. PMID: 25084986
21. Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. PMID: 25025572
22. Therapeutic concentrations of cyclosporine and tacrolimus can inhibit glucose uptake independent of insulin signaling by removing GLUT4 from the cell surface via an increased rate of endocytosis. PMID: 25004245
23. shRNA-mediated down-regulation of GLUT4 diminishes glucose uptake and induces metabolic reprogramming by reallocating metabolic flux to oxidative phosphorylation. PMID: 24931902
24. findings suggest that the AA genotype and A allele of SLC2A4 promoter, rs5418 were associated with top-level endurance performance in the northern Han Chinese population. PMID: 24533495
25. Inhibition of PGC-1A suppresses cell proliferation probably by downregulation of VEGF and GLUT-4. PMID: 24402435
26. GLUT4 gene SNPrs5417 is associated with obstructive sleep apnea syndrome in hypertensive population. PMID: 24410986
27. Crystal structure of Myo1c/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin-stimulated glucose uptake. PMID: 24636949
28. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 translocation. PMID: 24216110
29. it is clear that pharmacogenomics has great potential to select subjects more or less prone to regulate the SLC2A4 gene and consequently glycemic homeostasis. PMID: 23746177
30. Insulin-stimulated GLUT4 trafficking differs between t-tubules and sarcolemma; contraction-induced GLUT4 trafficking does not differ between membrane surfaces.[review] PMID: 23072821
31. Data suggest that 11 weeks of daily moderate- or high-intensity aerobic exercise improves insulin resistance and up-regulates glucose transport and GLUT4 in skeletal muscle (but not in white adipose tissue) of young overweight men. PMID: 23800880
32. findings showed that adipose insulin-responsive glucose transporter type 4 (GLUT4) gene expression changes were more related to insulin resistance and type 2 diabetes rather than to obesity PMID: 21604201
33. Data suggest that 17 beta-estradiol enhances the the glucose uptake, activates PI3K/Akt signaling pathway, leading to translocation of glucose transporter 4 to the plasma membrane in an ERalpha-dependent manner. PMID: 23546602
34. Data from normally cycling young women suggest that expression of GLUT4 in endometrium is higher in follicular phase (as compared to luteal phase) and is localized to epithelial cells (as compared to stromal cells). PMID: 22971162
35. Insufficient GLUT4 translocation results in decreased glucose supply in patients with critical illness myopathy. PMID: 23239154
36. HbA1c is significantly higher in the most frequent GA haplotype compared with the second frequent AC haplotype (5.2% vs. 5.1%, P = 0.004). Genetic variations, rs5418 and rs2654185 in GLUT4 gene are associated with HbA1c level in Japanese men. PMID: 22673408
37. CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action PMID: 22992739
38. These data provide evidence for the existence of GLUT4 in the endocrine pancreas and indicate a physiological relevance of this glucose transporter as well as characteristic changes in diabetic disease. PMID: 22488520
39. data reveal that T(3) rapidly increases glucose uptake in L6-GLUT4myc cells, which, at least for 30 minutes, did not depend on an increment in GLUT4 at the cell surface yet potentiates insulin action. PMID: 22663547
40. The role of CaMKII in regulating GLUT4 expression in skeletal muscle. PMID: 22496345
41. The introduction of beta(2)-adrenoceptors and GLUT4 into these cells caused increased glucose uptake in response to beta-adrenoceptor agonists. PMID: 21883150
42. GLUT4 translocation and expression is induced by (+)-Rutamarin PMID: 22384078
43. Both adipose tissues have lower GLUT4 levels in patients with coronary artery disease; these findings suggest a differential regulation of RBP4 production in epicardial adipose tissue and subcutaneous adipose tissue, possibly influenced by local factors. PMID: 21645024
44. Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer. PMID: 22452979
45. The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage. PMID: 22403297
46. investigation of mechanisms involved in insulin-stimulated translocation of GLUT4 from intracellular sites to sarcolemma; studies involve glucose metabolism in transgenic mice expressing a GLUT4 fusion protein (HA-GLUT4-GFP) in skeletal muscle/heart PMID: 22297303
47. GLUT4 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance. PMID: 22114711
48. genetic association studies of GLUT4 in a population in India: An SNP in GLUT4 (rs5435, C/T) is associated with type 2 diabetes. ACGT haplotypes of rs5418 (A/G), rs5435 (C/T), rs5421 (C/G), and T/G variant in 3-UTR showed protection against diabetes. PMID: 21668369
49. insulin resistance is observed in patients with advanced liver cirrhosis but may not be correlated with the skeletal contents of GLUT4 protein and mRNA PMID: 21796809
50. critical roles of the N-glycan chain in quality control as well as intracellular trafficking of GLUT4. PMID: 21757715
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相關(guān)疾病：

Diabetes mellitus, non-insulin-dependent (NIDDM)
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.
蛋白家族：

Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
組織特異性：

Skeletal and cardiac muscles; brown and white fat.
數(shù)據(jù)庫鏈接：

HGNC: 11009

OMIM: 125853

KEGG: hsa:6517

STRING: 9606.ENSP00000320935

UniGene: Hs.380691

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