SLC24A4 Antibody
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中文名稱：SLC24A4兔多克隆抗體
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貨號：CSB-PA939107
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA939107(SLC24A4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：SLC24A4
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別名：Na(+)/K(+)/Ca(2+)-exchange protein 4 antibody; NCKX4 antibody; NCKX4_HUMAN antibody; SHEP6 antibody; SLC24A2 antibody; SLC24A4 antibody; Sodium/potassium/calcium exchanger 4 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 4 antibody; Solute carrier family 24 member 4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human SLC24A4
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.
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基因功能參考文獻：
- no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE) epsilon4 carriers nor non-carriers after adjusting for age and gender PMID: 27215332
- pigment cells express robust, functional NCKX4 activity PMID: 27093457
- mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients. PMID: 27129268
- The expressions of NCX1 and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels. PMID: 25500693
- enamel maturation is dependent upon STIM1 and SLC24A4 function, and that there are important differences in the Ca(2+) transcellular transport systems used by secretory- and maturation-stage ameloblasts. PMID: 24621671
- Brain DNA methylation in sLC24A4 was associated with pathological Alzheimer disease. PMID: 25365775
- These findings support a key role for SLC24A4 in calcium transport during enamel formation. PMID: 23375655
- Taken together, these data demonstrate a potentially important role for NCX1 in control of Ca2+ homeostasis and link store depletion via STIM1 directly with NCX activation. PMID: 21126331
- identification and sequencing, as well as mapping to chromosomal region 14q32 PMID: 12379639
- IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. PMID: 18483556
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相關疾病：Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5)
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亞細胞定位：Cytoplasm. Cell membrane; Multi-pass membrane protein.
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蛋白家族：Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
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組織特異性：Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.
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數據庫鏈接：
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