SIX1 Antibody, Biotin conjugated

說明書

中文名稱：

SIX1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA618986LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SIX1 Polyclonal antibody
Uniprot No.：

Q15475
基因名：

SIX1
別名：

BOS3 antibody; DFNA23 antibody; Homeobox protein SIX1 antibody; OTTHUMP00000179042 antibody; Sine oculis homeobox homolog 1 antibody; SIX homeobox 1 antibody; SIX1 antibody; SIX1_HUMAN antibody; TIP39 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Homeobox protein SIX1 protein (144-262AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1. Promotes brown adipocyte differentiation.
基因功能參考文獻：
1. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients PMID: 29455928
2. Knockdown of SIX1 increased cell ROS levels and autophagy, promoted cell apoptosis, and enhanced TAX sensitivity of HepG2 cells. PMID: 29656300
3. SIX1/EYA1 mutations might be partially responsible for conotruncal heart defects. PMID: 29043394
4. We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma . PMID: 29190129
5. SIX1 is a potential target gene of miR-30a and down-regulation of SIX1 by siRNA inhibited proliferation and invasion of prostate cancer cells. PMID: 28573504
6. Six1 is overexpressed in human primary pancreatic ductal adenocarcinomas and that its inhibition results in a decreased tumour progression in vitro and in vivo. PMID: 28388884
7. in non-small cell lung cancer, SIX1-5 were associated with the greater possibility of the tumorigenesis PMID: 27821176
8. SIX1 oncoprotein is aberrantly expressed in the endometrium following developmental exposure to estrogenic chemicals, correlates with uterine cancer, and is a biomarker in human endometrial cancers PMID: 27259717
9. SIX homeobox 1 (SIX1) regulates cellular senescence by a p16INK4A (p16)-dependent mechanism. PMID: 26500063
10. Studies strongly suggest that Six1 overexpression promotes CRC growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM. MAPK activation may be a pivotal event in Six1-associated tumor progression. PMID: 28199476
11. Restoration of SIX1 was sufficient to abolish proliferation, migration and invasion induced by miR-362 overexpression in cervical cancer cells. The newly identified miR-362/SIX1 pathway provides insight into cervical cancer progression, and may represent a novel therapeutic target. PMID: 27878258
12. study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years PMID: 27260188
13. results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals. PMID: 27241908
14. miR-188 suppresses proliferation and invasion by targeting SIX1 in oral squamous cell carcinoma cells. PMID: 26490981
15. Upregulation of Six1 could downregulate miR-204-5p expression. PMID: 26408179
16. Mutations of SIX1 gene underlie Wilms tumor recurrences. PMID: 26802027
17. Six1 signaling has a role in paclitaxel-dependent apoptosis in MCF-7 cell line PMID: 26773176
18. Six1 mutations/gene deletion are unlikely to be a major cause of nonsyndromic CAKUT. PMID: 24899122
19. Data show that the protein domain interfaces may represent therapeutic targets in homeo domain protein SIX1-positive Hodgkin lymphoma (HL) subsets. PMID: 26473286
20. Data show that both Ezrin and SIX1 proteins are highly expressed in alpha fetoprotein-negative hepatocellular carcinoma (HCC) and significantly related with the TNM stage. PMID: 26927385
21. These data suggest differential SIX-factor regulation might have contributed to species differences in nephron progenitor programs such as the duration of nephrogenesis and the final nephron count PMID: 26884396
22. Single nucleotide polymorphism in SIX1 gene is associated with primary open angle glaucoma. PMID: 25798827
23. High expression of SIX1 is an independent prognostic marker in colorectal cancer. PMID: 25951369
24. Three causative genes for BOR syndrome have been reported thus far: EYA1, SIX1, and SIX5, but the causative genes for approximately half of all BOR patients remain unknown.[review] PMID: 24730701
25. SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model. PMID: 25555392
26. Six1 plays an important role in the TIC population in luminal breast cancers and induces a TIC phenotype by enhancing both TGF-beta and ERK signaling. PMID: 22765220
27. SIX1 plays an important role in the progression ofhepatocellular carcinoma PMID: 25031720
28. in tumors with DGCR8 E518K and DROSHA exon 29 (miRNAPG-HS) mutations ... greater prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1/2 Q177R mutations PMID: 25670082
29. Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes PMID: 25670083
30. Six1 overexpression in HPV16-immortalized keratinocytes increased cell proliferation and promoted cell migration and invasion by inducing epithelial-mesenchymal transition. PMID: 25463612
31. HDAC5 promoted the Six1 expression. PMID: 24706304
32. tumor cells that expressed high levels of SIX1 could promote lymphangiogenesis and counteract the negative effects of TGFbeta on lymphangiogenesis by increasing the expression of VEGF-C PMID: 25142796
33. Results suggest that the increase of SIX1 expression could promote tumorigenesis, progression and invasive growth of cervical cancer by promoting DNA replication. PMID: 24970368
34. In breast phyllodes tumors, Six1 and Pax3 expression is correlated with tumour grade, unfavourable clinicopathological parameters and poorer clinical outcome, suggesting that both proteins may play a role in malignant progression. PMID: 24438019
35. SIX1 was frequently upregulated in gastric adenocarcinoma specimens and its overexpression could potentially be used as an independent predictor of prognosis and survival time in patients with gastric cancer PMID: 24866365
36. Suggest that lentivirus-mediated Six1 inhibition may represent a novel therapeutic approach for treatment of colorectal cancer. PMID: 24551283
37. Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes. PMID: 24574515
38. In colorectal cancer cells, SIX1 is a target gene for regulation of cell migration and tumor invasion. PMID: 24593661
39. data suggested that Six1 might be involved in the promotion of growth, proliferation, and migration of osteosarcoma cell lines PMID: 24114014
40. These results suggest that SIX1/alpha5beta1 might be considered as valuable marker for metastatic potential of cervical cancer cells, or a therapeutic target in cervical cancer treatment. PMID: 24613848
41. SIX1 overexpression is associated with pancreatic ductal adenocarcinoma. PMID: 24263054
42. these data suggest that Six1 may function as an important modifier of the paclitaxel response in breast cancer cells, and serve as a potential target for overcoming paclitaxel resistance in breast cancer. PMID: 24184484
43. Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression. PMID: 23527134
44. Given that SIX1 and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types PMID: 23435380
45. It is required downstream of Six1 to induce these phenotypes. PMID: 22286770
46. SIX1 overexpression contributes to epithelial-mesenchymal transition partly through repression of miR-200-family expression and activation of ZEB1 in colorectal cancer. PMID: 22286765
47. The identification of SIX1 and CDKN2B variant was found to be associated more strongly with advanced open-angle glaucoma. PMID: 22840486
48. An exception is the predominant expression of SIX1 in blastemal cells, hereby identifying this protein as a candidate marker for blastema. PMID: 22180226
49. In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome. PMID: 22447252
50. A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer. PMID: 22466647
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相關疾病：

Deafness, autosomal dominant, 23 (DFNA23); Branchiootic syndrome 3 (BOS3)
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

SIX/Sine oculis homeobox family
組織特異性：

Specifically expressed in skeletal muscle.
數據庫鏈接：

HGNC: 10887

OMIM: 601205

KEGG: hsa:6495

STRING: 9606.ENSP00000247182

UniGene: Hs.633506

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