SHCBP1 Antibody

中文名稱：

SHCBP1兔多克隆抗體
貨號：

CSB-PA847699LA01HU
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SHCBP1 Polyclonal antibody
Uniprot No.：

Q8NEM2
基因名：

SHCBP1
別名：

FLJ22009 antibody; PAL antibody; Protein expressed in Activated Lymphocytes antibody; SHC binding and spindle associated 1 antibody; SHC SH2 domain-binding protein 1 antibody; SHCBP_HUMAN antibody; Shcbp1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human SHC SH2 domain-binding protein 1 protein (211-500AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SHCBP1 Antibody (CSB-PA847699LA01HU)，的標記方式是Non-conjugated。對于SHCBP1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA847699LB01HU	SHCBP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA847699LC01HU	SHCBP1 Antibody, FITC conjugated
Biotin	CSB-PA847699LD01HU	SHCBP1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
基因功能參考文獻：
1. SHCBP1 was found highly expressed in SS cell lines and tissues, which was linked to the poor clinical prognosis and was implicated in SS aggressive progression. SHCBP1 regulated invasion and metastasis by modulating the TGF-beta1/Smad signaling pathway and promoting the EMT in SS. PMID: 29020987
2. Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
3. Immunohistochemical analysis revealed SHCBP1 was significantly up-regulated in breast cancer tissues compared with adjacent normal tissues (82 of 128, 64%). Over-expressed SHCBP1 was correlated with advanced clinical stage and poorer survival. Ablation of SHCBP1 inhibited the proliferation in vitro. PMID: 27129942
4. This study gives novel insight into the role of SHCBP in cytokinesis completion. PMID: 25486361
5. Knockdown of SHCBP1 induced cell cycle delay. PMID: 24289556
6. The central region of SHCBP1 was found to bind to measles virus C protein, as well as the phosphoprotein, but the two viral proteins did not compete for SHCBP1 binding. PMID: 23804634
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亞細胞定位：

Midbody. Cytoplasm, cytoskeleton, spindle.
數據庫鏈接：

HGNC: 29547

OMIM: 611027

KEGG: hsa:79801

STRING: 9606.ENSP00000306473

UniGene: Hs.123253

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