SHC2 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

P98077
基因名：

SHC2
別名：

SHC2 antibody; SCK antibody; SHCB antibody; SHC-transforming protein 2 antibody; Protein Sck antibody; SHC-transforming protein B antibody; Src homology 2 domain-containing-transforming protein C2 antibody; SH2 domain protein C2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Sck.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
基因功能參考文獻(xiàn)：
1. Sck was identified as a novel molecule indispensable for CD95's activation of the PI3K and MAPK pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma. PMID: 25613377
2. SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population. PMID: 24170347
3. Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy. PMID: 21658278
組織特異性：

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
數(shù)據(jù)庫鏈接：

HGNC: 29869

OMIM: 605217

KEGG: hsa:25759

STRING: 9606.ENSP00000264554

UniGene: Hs.30965

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