SH3BP2 Antibody, FITC conjugated

說(shuō)明書(shū)

中文名稱：

SH3BP2兔多克隆抗體, FITC偶聯(lián)
貨號(hào)：

CSB-PA021224LC01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SH3BP2 Polyclonal antibody
Uniprot No.：

P78314
基因名：

SH3BP2
別名：

3BP-2 antibody; 3BP2 antibody; 3BP2_HUMAN antibody; Abl SH3 binding protein 2 antibody; Cherubism antibody; CRBM antibody; CRPM antibody; FLJ42079 antibody; FLJ54978 antibody; RES4-23 antibody; SH3 domain binding protein 2 antibody; SH3 domain-binding protein 2 antibody; Sh3bp2 antibody; TNFAIP3 interacting protein 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human SH3 domain-binding protein 2 protein (165-301AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
基因功能參考文獻(xiàn)：
1. All members featured a heterozygous missense c.1244G>C; p.Arg415Pro SH3BP2 mutation PMID: 28721660
2. The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. PMID: 25810396
3. A c.1244G>A (p.Arg415Gln) mutation in SH3BP2 gene causes cherubism in a Turkish family PMID: 24608212
4. Authors conclude that a novel p.Asp419Tyr alteration in SH3BP2 to be a cherubism-causing mutation in a Turkish family. PMID: 23083484
5. In the first family, a missense mutation Arg415Gln was found in exon 9 of SH3BP2 in all affected individuals. The unaffected individuals did not have the mutation. In the second family, a missense mutation Pro418Thr was identified in exon 9 of the SH3BP2 PMID: 22795151
6. These results demonstrate that PARP1 regulates expression of SH3BP2. PMID: 22820184
7. P416R mutation of 3BP2 causes the gain of function in B cells by increasing the interaction with specific signaling molecules. PMID: 21794028
8. if a primary genetic defect is the cause for CGCG it is either located in SH3BP2 gene exons not yet related to cherubism or in a different gene. PMID: 21680150
9. The SH-3BP-2 mutation may participate in the differentiation and maturation of osteoclast-like cells in the lesion of cherubism. PMID: 19576004
10. over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and PLCgamma2. PMID: 20872577
11. No SH3BP2 gene mutation was found in PGCL. PMID: 20002873
12. Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. PMID: 12200378
13. 3BP2 may regulate b cell receptor-mediated gene activation through Vav proteins. PMID: 15345594
14. Adaptor protein SH3BP2 regulates transcription factors through its tyrosine phosphorylation and SH2 domain. PMID: 15751964
15. CD244-3BP2 association regulates cytolytic function but not IFN-gamma release PMID: 16177062
16. no mutations...in giant cell granuloma PMID: 16713042
17. How SH3BP2 affects leukocyte signaling and influences cherubism PMID: 16802602
18. a novel A1517G missense mutation at the SH3BP2 gene in a Chinese family with multiple affected individuals with cherubism was identified PMID: 17147794
19. Mutated in a rare human disease involved in cranial-facial development called cherubism, suggesting a role for 3BP2 in regulating osteoclast and hematopoietic cell function. [REVIEW] PMID: 17156730
20. unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55 PMID: 17306257
21. A new mutation in a family affected with cherubism PMID: 17321449
22. People with Giant Cell Granuloma of the Jaw do not harbour cherubism-related germline SH3BP2 mutations. PMID: 17544554
23. Point mutations in the SH3BP2 gene have been revealed in cherubism patients. PMID: 18596838
24. 2 novel mutations were found; heterozygous missense mutation c.1442A>T (Q481L) in exon 11 in one sporadic case of CGCL and heterozygous germline and tumor tissue missense mutation c.320C>T (T107M) in exon 4 in one patient with cherubism. PMID: 19017279
25. 3BP2 induces the protein complex with cellular signaling molecules through phosphorylation of Tyr(183) and SH2 domain leading to the activation of NFAT in B cells PMID: 19833725
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相關(guān)疾病：

Cherubism (CRBM)
組織特異性：

Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 10825

OMIM: 118400

KEGG: hsa:6452

STRING: 9606.ENSP00000422168

UniGene: Hs.167679

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