Immunofluorescence staining of MCF-7 cells with CSB-PA761499LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
May contribute to specialized endoplasmic reticulum functions in neurons.
基因功能參考文獻:
SEZ6L2 can partially correct the cathepsin D hypersecretion. PMID: 26698217
These results provide an extensive ascertainment of the genetic variability of SEZ6L2 in human populations and do not support a major role for SEZ6L2 sequence variations in the susceptibility to autism spectrum disorders. PMID: 21394203
significant association between autism and a coding variant in the seizure-related gene SEZ6L2 gene; SEZ6L2 expression in human fetal brain was highest in post-mitotic cortical layers, hippocampus, amygdala, and thalamus PMID: 19242545
亞細胞定位:
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Detected on cell surface of lung-cancer.