SETMAR Antibody
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中文名稱：SETMAR兔多克隆抗體
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貨號：CSB-PA050020
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規(guī)格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：SETMAR
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別名：Histone lysine N methyltransferase antibody; Histone lysine N methyltransferase SETMAR antibody; Hsmar 1 antibody; Hsmar1 antibody; Mariner transposase Hsmar1 antibody; Metnase antibody; SET domain and mariner transposase fusion antibody; SET domain and mariner transposase fusion gene antibody; SET domain and mariner transposase fusion gene containing protein antibody; SET domain and mariner transposase fusion gene-containing protein antibody; Setmar antibody; SETMR_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human SETMAR.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining. Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A.
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基因功能參考文獻：
- Various SETMAR proteins can be synthesized in human glioblastoma that may each have specific biophysical and/or biochemical properties and characteristics. PMID: 28038463
- These results suggest that Metnase enhances Exo1-mediated exonuclease activity on the lagging strand DNA by facilitating Exo1 loading onto a single strand gap at the stalled replication fork. PMID: 27974460
- The SET domain is needed for the 5' end of ss-overhang cleavage with fork and non-fork DNA without affecting the Metnase-DNA interaction. This domain has a positive role in restart of replication fork and the 5' end of ss-overhang cleavage. PMID: 26437079
- methylation of snRNP70 by SETMAR regulates constitutive and/or alternative splicing PMID: 25795785
- Metnase may possess an important role in DNA repair, topoisomerase II function, and the maintenance of stemness during colon cancer development. PMID: 25333365
- 293 T transfected with Metnase revealed a large number of rescued plasmids. PMID: 24655462
- found known and novel SETMAR splice variants to be significantly increased in acute myeloid leukemia PMID: 24607956
- a single mutation DDN(610) --> DDD(610), which restores the ancestral catalytic site, results in loss of function in Metnase PMID: 24573677
- phosphorylation of Metnase S495 differentiates between these two functions, enhancing DSB repair and repressing replication fork restart. PMID: 22231448
- a role for Metnase's endonuclease activity in promoting the joining of noncompatible ends PMID: 21491884
- Data show that DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein. PMID: 21124928
- DNA repair protein Metnase (also SETMAR), which has a SET histone methylase domain, localized to an induced DSB and directly mediated the formation of H3K36me2 near the induced DSB PMID: 21187428
- results establish Metnase as a key factor that promotes restart of stalled replication forks, and implicate Metnase in the repair of collapsed forks. PMID: 20457750
- hPso4, once it forms a complex with Metnase, negatively regulates Metnase's TIR binding activity PMID: 20416268
- Metnase is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA and establishes a relationship among histone modification, DNA repair, and integration. PMID: 16332963
- These data suggest that vectors based on the Himar1 transposable element, in conjunction with the hyperactive mutant transposase C9, may be suitable vectors for gene therapy applications. PMID: 16989604
- SETMAR is unlikely to catalyze transposition in the human genome, although the nicking activity may have a role in the DNA repair phenotype. PMID: 17130240
- The activities of the SETMAR protein on transposon ends are described. PMID: 17403897
- Results suggest that Metnase's DNA cleavage activity, unlike those of other eukaryotic transposases, is not coupled to its sequence-specific DNA binding. PMID: 17877369
- hPso4 is necessary to bring Metnase to the DSB sites for its function(s) in DNA repair PMID: 18263876
- Metnase physically interacts and co-localizes with Topoisomerase IIalpha, the key chromosome decatenating enzyme. PMID: 18790802
- myeloid leukemia cells fail to arrest at the mitotic decatenation checkpoint, and their progression through this checkpoint is regulated by the DNA repair component Metnase (also termed SETMAR) PMID: 19458360
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亞細胞定位：Nucleus. Chromosome.
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蛋白家族：Class V-like SAM-binding methyltransferase superfamily; Mariner transposase family
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組織特異性：Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
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數據庫鏈接：
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