SERPINH1 Antibody

說明書

中文名稱：

SERPINH1兔多克隆抗體
貨號：

CSB-PA021087ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: Serpin H1 antibody at 2μg/ml
Lane 1: NIH/3T3 whole cell lysate
Lane 2: A2780 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021087ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA021087ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SERPINH1 Polyclonal antibody
Uniprot No.：

P50454
基因名：

SERPINH1
別名：

47 kDa heat shock protein antibody; 47 kDa heat shock protein precursor antibody; Arsenic transactivated protein 3 antibody; Arsenic-transactivated protein 3 antibody; AsTP 3 antibody; AsTP3 antibody; CBP 1 antibody; CBP 2 antibody; CBP1 antibody; CBP2 antibody; Cell proliferation-inducing gene 14 protein antibody; Collagen binding protein 1 antibody; Collagen binding protein 2 antibody; Collagen binding protein antibody; Collagen-binding protein 2 antibody; Collagen-binding protein antibody; Colligen antibody; Colligin 1 antibody; Colligin 2 antibody; Colligin antibody; colligin-1 antibody; colligin-2 antibody; gp46 antibody; Heat shock protein 47 antibody; Heat-shock protein 47 antibody; HGNC 1547 antibody; Hsp 47 antibody; J6 antibody; OI10 antibody; PIG 14 antibody; PIG14 antibody; PPROM antibody; Proliferation inducing gene 14 antibody; Proliferation inducing gene 14 protein antibody; RA A47 antibody; RA-A47 antibody; Rheumatoid arthritis antigen A 47 antibody; rheumatoid arthritis antigen A-47 antibody; Rheumatoid arthritis related antigen RA A47 antibody; Rheumatoid arthritis-related antigen RA-A47 antibody; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2) antibody; Serine or cysteine proteinase inhibitor clade H member 1 antibody; Serine or cysteine proteinase inhibitor clade H member 2 antibody; SERPH_HUMAN antibody; Serpin H1 antibody; Serpin peptidase inhibitor clade H member 1 antibody; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody; Serpin peptidase inhibitor, clade H, member 1 antibody; SERPINH1 antibody; SERPINH2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serpin H1 protein (139-418AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
基因功能參考文獻：
1. Our present data suggest that HSP47 is an important prognostic factor and an attractive therapeutic target in laryngeal squamous cell carcinoma (LSCC)due to its influence on the biological behaviour of LSCC cells PMID: 28849239
2. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
3. These observations indicate that this system is appropriate for detecting the interaction between HSP47 and collagen, and could be applied to high-throughput screening for drugs capable of suppressing and/or curing fibrosis. PMID: 29438711
4. miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression. PMID: 27477081
5. HSP47 expression in patients with colorectal cancer and the number of HSP47-positive spindle cells in the tumor stroma were significantly higher compared with those in adjacent normal colonic mucosa, and the number of the latter cells increased with tumor progression. PMID: 27925182
6. The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the HSP47 pathway. PMID: 28179603
7. Overexpression of LOXL2 and SERPINH1 was observed in clinical specimens of lung cancer and fibrotic lesions. Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF, suggesting that these genes are involved in the pathogenesis of these two diseases. PMID: 27488440
8. The changes in the SERPINH1 and SERPINF1 genes in patients with osteogenesis imperfect were synonymous polymorphisms or missense changes located in non-coding regions. PMID: 27706701
9. Overexpression of HSP47 is associated with poor prognosis in patients with esophageal squamous cell carcinoma and this is consistent with the function of HSP47 in terms of increased cell proliferation and colony formation. PMID: 25953518
10. A novel homozygous variant in SERPINH1 associated with a severe, lethal presentation of osteogenesis imperfecta with hydranencephaly. PMID: 27677223
11. The present study demonstrates that HSP47 promotes glioma angiogenesis and highlights the importance of HSP47 as an attractive therapeutic target of GBM. PMID: 25758142
12. Although the chemical chaperone 4-PBA partially restores the solubility of the Hsp47 OI mutants, collagen-binding activity of Hsp47 was not improved. PMID: 26692483
13. Data show that the expression of heat shock protein 47 (HSP47) was increased in the peripheral blood mononuclear cells and plasma from scleroderma patients. PMID: 26091621
14. Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect. PMID: 25510505
15. In patients with schistosomiasis japonica, TGF-beta1 participates not only in the inflammatory process, but also in the fibrotic process in which Hsp47 and CTGF probably play a key role. PMID: 25111595
16. Hsp47 expression promotes cancer progression in part by enhancing deposition of extracellular matrix proteins. PMID: 25744716
17. IL-17A-induced HSP47 expression is involved in collagen I expression in intestinal subepithelial myofibroblasts, which might contribute to intestinal fibrosis in Crohn's disease. PMID: 24534724
18. silencing of the HSP47 gene significantly inhibited cell migration and invasion in cancer cells and the expression of HSP47 was upregulated in cancer tissues and cervical intraepithelial neoplasia, as demonstrated by immunostaining. PMID: 24141696
19. miR-29b down-regulates HSP47 and LOX expression. PMID: 24650661
20. HSP47 is a novel glioma-associated antigen PMID: 24623841
21. TRAIL induced HSF1 inactivation leads to the suppression of Hsp47-dependent collagen production in activated human hepatic stellate cells. PMID: 23587601
22. Correlative Hsp47 expression in fibroblasts with bFGF in inflammatory cells may contribute to stromal fibrosis and obstruction in colorectal carcinoma PMID: 23265436
23. NMR and mutational identification of the collagen-binding site of the chaperone Hsp47 PMID: 23049894
24. Hsp47 may be related to the TGF-beta1-induced transdifferentiation of human Tenon's fibroblasts to myofibroblasts. PMID: 22967132
25. Hsp47 recognizes the triple-helix form of procollagen in vitro and in vivo. PMID: 22235129
26. Overexpression of HSP47 decreased the secretion of heterotrimers containing the mutant collagen alpha5(IV) chain. PMID: 21187648
27. HSP47 and fascin expression may play role in the pathogenesis of invasive ductal carcinoma of the breast and prostatic adenocarcinoma because their expression is significantly higher than their normal counterpart. PMID: 20701077
28. We conclude that colligin 2 is expressed in all cellular components of glioma blood vessels and may serve as a general marker for active angiogenesis PMID: 19067716
29. down-regulated KLF4, CHGA, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA is an 8-gene signature for gastric cancer PMID: 20043075
30. Increased heat shock protein 47 expression is associated with esophageal squamous cell carcinoma. PMID: 20112500
31. The enhancement of HSP47 expression by TGF-beta and IL-1 beta has been confirmed in embryonic lung fibroblasts. PMID: 11994473
32. induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis PMID: 12061838
33. Results indicate a novel means by which type I collagen production is regulated by the endoplasmic reticulum constituent, Hsp47. PMID: 12163502
34. Modulates the production of the endostatin precursor collagen XVIII in head and neck carcinomas PMID: 12174873
35. levels of HSP47 protein and autoantibodies to HSP47 in the sera of patients with rheumatic autoimmune diseases PMID: 12659832
36. gene expression profiling in epidermolysis bullosa acquisita PMID: 12824005
37. high levels of expression of Hsp47 and adult and oncofetal fibronectin in Dupuytren's contracture suggests that cell-mediated alterations in the extracellular environment may play an important role in the disease process PMID: 15047128
38. HSP47 has a role in aging and photoaging in human fibroblasts PMID: 15247019
39. The surface-exposed RA-A47 may induce autoantibodies and inflammatory reactions in autoimmune disease situations such as rheumatoid arthritis. PMID: 15389525
40. HSP47 is constitutively expressed in human hepatic stellate cells and may be a target for antifibrotic therapy. PMID: 15806139
41. Our results suggest the existence of different fibrotic pathways among these groups involved in the expression of HSP47 and type I procollagen. PMID: 15955241
42. results suggest nitric oxide has dual effects on collagen synthesis by fibroblasts: the direct stimulation of collagen synthesis due to the up-regulation of procollagen alphaI(1) mRNA, and an indirect effect through the increase of HSP47 mRNA expression PMID: 16171977
43. analysis of the client recognition mechanism of HSP47 PMID: 16326708
44. analysis of recognition of the collagen triple helix by chaperone HSP47 PMID: 16484215
45. A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans. PMID: 16938879
46. The anti-fibrotic effect of pirfenidone may be mediated through direct inhibition of collagen type I expression and inhibition of HSP47 expression in lung fibroblasts. PMID: 18093617
47. HSP47-positive fibroblasts were main constituent cell of dermatofibroma. PMID: 18095990
48. These studies define a new haplotype in the SERPINH1 gene that modifies risk of an adverse obstetrical outcome. PMID: 18205191
49. During keratin preparation from cultured human tumor cell lines, Hsps might be associated with keratin expression in tumor cells PMID: 18293509
50. Hsp47 was exposed on surface of GPVI-activated platelets; inhibition of Hsp47 abolished platelet aggregation in response to collagen, but partially reduced aggregation in response to other agonists; propose Hsp47 may play a role in hemostasis & thrombosis PMID: 19341245
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相關疾病：

Osteogenesis imperfecta 10 (OI10)
亞細胞定位：

Endoplasmic reticulum lumen.
蛋白家族：

Serpin family
數據庫鏈接：

HGNC: 1546

OMIM: 600943

KEGG: hsa:871

STRING: 9606.ENSP00000350894

UniGene: Hs.596449

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