SERPINE2 Antibody
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中文名稱：SERPINE2兔多克隆抗體
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貨號：CSB-PA021082GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：SERPINE2
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別名：GDN antibody; GDN_HUMAN antibody; GDNPF antibody; Glia derived nexin antibody; Glia-derived nexin antibody; Glial derived neurite promoting factor antibody; P17 antibody; Peptidase inhibitor 7 antibody; Pi-7 antibody; Plasminogen activator inhibitor type 1; member 2 antibody; PN-1 antibody; PN1 antibody; PNI antibody; Protease inhibitor 7 antibody; Protease nexin 1 antibody; Protease nexin I antibody; Serpin E2 antibody; Serpin family E member 2 antibody; Serpin peptidase inhibitor; clade E (nexin; plasminogen activator inhibitor type 1); member 2 antibody; SERPINE 2 antibody; Serpine2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human SERPINE2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
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基因功能參考文獻：
- Study identified a secreted protein, SerpinE2 or glia-derived nexin, as causative for the highly invasive potential of slow-cycling melanoma cells. PMID: 28925403
- miR-199a-3p overexpression inhibited the expression of the extracellular serine protease inhibitor E2 (SerpinE2). PMID: 28677735
- The role of PN-1 in the pathogenesis of intervertebral disk degeneration PMID: 27460424
- SerpinE2 is required in the extracellular milieu of breast tumors where it acts in multiple ways to regulate tumor matrix deposition, thereby controlling tumor cell dissemination. PMID: 27793045
- Single nucleotide polymorphisms in EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population. PMID: 27193053
- high expression of SerpinE2 in osteosarcoma stimulates cell proliferation, promotes drugresistance, and results in poor survival by regulating CDK4 and cyclin D1. PMID: 27221371
- The results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors. PMID: 28255192
- We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005). PMID: 26318431
- together, these data demonstrate that SERPINE2 might prevent cartilage catabolism by inhibiting the expression of MMP-13, one of the most relevant collagenases, involved in cartilage breakdown in OA. PMID: 26305372
- The results suggest that the rs3795879 polymorphism of SERPINE2 is not a risk factor for chronic obstructive pulmonary disease. PMID: 26214473
- aberrant Serpine2/Pn-1 is required for proliferation of human and mouse medulloblastoma cells. PMID: 25901736
- Our findings indicate that upregulated SERPINE2 may contribute to the aggressive phenotype of gastric cancer and suggest that SERPINE2 can be used as a novel prognostic factor and anticancer target in patients with gastric cancer. PMID: 25359682
- MAGI2, SERPINE2, and NT5C3B expression levels are associated with airway wall thickening and additionally with bronchial inflammation, emphysema, and lung function, respectively, all features of chronic obstructive pulmonary disease. PMID: 25517131
- Haplotypes carrying major alleles of rs729631 (C), rs975278 (G), rs7583463 (C) of SERPINE2 had protective effect on lung function amongst South Indian male smokers with COPD. PMID: 24587150
- role in lung homeostasis and pulmonary fibrosis PMID: 25199049
- SERPINE2 and PLAU are involved in cumulus expansion and oocyte maturation. PMID: 24023701
- Studies suggest that protease nexin 1 as a marker of prostate cancer. PMID: 23385179
- PN1 regulates Hh signaling by decreasing protein levels of the Hh ligand Sonic (SHH) and its downstream effectors. PMID: 23041623
- crystal structures of PN1 in complex with heparin and catalytically inert thrombin suggest a unique 2-step mechanism of thrombin recognition involving rapid electrostatics-driven association PMID: 22618708
- PN-1 has direct antiangiogenic properties and is a yet-unrecognized player in the angiogenic balance PMID: 22331468
- Data suggested that there was no significant association between SERPINE2 polymorphism and COPD susceptibility in the Chinese Han population. PMID: 22028159
- SERPINE2 gene is a chronic obstructive pulmonary disease susceptibility gene, and block 1 of SERPINE2 appears to be the genetic variant region that affects the Han Chinese. PMID: 21611750
- The variant allele of the rs729631 SNP was found to pose over two-fold risk for overall panlobular changes and over four-fold risk for pathological panlobular changes. PMID: 22145704
- Results weakly support SERPINE2 as a Dutch hypothesis candidate gene through nominally significant associations with asthma and related traits. PMID: 21436250
- data identify the temporal and spatial SERPINE2 distribution in the human placenta and suggest its possible role in modulating tissue remodeling of extravillous trophoblasts in the placenta during pregnancy. PMID: 21806836
- SERPINE2 protein is highly expressed in the endometrium during the secretory phase, indicating that it may participate in tissue remodeling involved in implantation. PMID: 21426587
- platelet PN-1 can be considered as a new important regulator of thrombolysis in vivo PMID: 21403095
- In cerebellum, thrombin can activate PAR-1 expression after ICH, and PN-1 appears quickly after Intracerebral hemorrhage in order to control the deleterious effect of thrombin. PMID: 20819545
- data indicate that serpinE2 is up-regulated by oncogenic activation of Ras, BRAF and MEK1 and contributes to pro-neoplastic actions of ERK signaling in intestinal epithelial cells. PMID: 20942929
- SERPINE2 may be a risk factor for the development of emphysema and its association with emphysema may be stronger in smokers. PMID: 21067581
- SERPINE2 was overexpressed in the ER-negative breast cancer group. PMID: 20805453
- human astrocytes express Pn-1 and astrocytic expression is regulated in a dynamic manner by injury-related factors PMID: 20623540
- SERPINE2, was previously identified as a COPD susceptibility gene in the chromosome 2q linkage region. Using independent genotyping data in 2 smaller studies in Boston and Norway the results were replicated. PMID: 20463177
- SERPINE2 was identified as a possible promoter of testicular germ cell tumors lymph node metastasis. PMID: 20035713
- Results suggest that the SERPINE2 gene contributes to the susceptibility to COPD. PMID: 19949669
- Platelet PN-1 is a key player in the thrombotic process, whose negative regulatory role has been, up to now, markedly underestimated. PMID: 19855083
- Elevated levels of GDN/PN1 and XIP mRNAs induced by Allitridi provide valuable molecular evidence for elucidating garlic's efficacies against neurodegenerative and inflammatory diseases. PMID: 11925594
- PN1 may play a much larger role in the modeling and remodeling of brain tissues during development and is not simply an extravasated thrombin clearance mechanism as previously suggested PMID: 12356769
- the 4G/4G-PAI-1 genotype might be a protective factor against atherothrombotic cerebral infarction (ACI), whereas the factor V point mutation (1691G-A) and the factor VII Arg/Gln353 gene polymorphism have not proved to be risk factors for ACI PMID: 12859287
- The pericyte expression of protease nexin 1 may provide endogenous anticoagulant activity. PMID: 16015279
- Arg15, Phe34, Pro13, and Arg20 are important for FXIa inhibition by PN2 Kunitz protease inhibitor domain PMID: 16085935
- SERPINE2 is a COPD-susceptibility gene and is likely influenced by gene-by-smoking interaction. PMID: 16358219
- This study shows that syndecan-1-mediated internalization of protease nexin-1 stimulated the Ras-ERK signaling pathway. PMID: 16741952
- Expression array analysis demonstrated association and repication of SERPINE2 as a potential COPD susceptibility gene. PMID: 16921128
- Protease nexin-1 forms complexes with thrombomodulin and modulates its anticoagulant activity. PMID: 17379830
- provides support for SERPINE2 as a COPD susceptibility gene PMID: 17446335
- Co-injection of pancreatic stellate cells and tumor cells dramatically enhances the invasive potential of SERPINE2-expressing SUIT-2 cells in nude mice. PMID: 17703087
- Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque. PMID: 18617644
- in severe COPD, SNPs in EPHX1 and SERPINE2 were associated with hypoxemia PMID: 19017876
- Here, we report that nexin-1 inhibits trypsin-4, and forms stable complexes only with this trypsin-isoenzyme. This result suggests that nexin-1 could modulate trypsin activity in brain where both nexin-1 and trypsin-4 are expressed. PMID: 19249338
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亞細胞定位：Secreted, extracellular space.
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蛋白家族：Serpin family
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