SEPSECS Antibody

說明書

中文名稱：

SEPSECS兔多克隆抗體
貨號：

CSB-PA021019GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HD40
基因名：

SEPSECS
別名：

DKFZp434B1417 antibody; Liver pancreas antigen antibody; Liver-pancreas antigen antibody; LP antibody; MGC161491 antibody; O phosphoseryl tRNA(Sec) selenium transferase antibody; O-phosphoseryl-tRNA(Sec) selenium transferase antibody; Sec synthase antibody; Selenocysteine synthase antibody; Selenocysteinyl tRNA(Sec) synthase antibody; Selenocysteinyl-tRNA(Sec) synthase antibody; Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase antibody; Sep tRNA:Sec tRNA synthase antibody; Sep-tRNA:Sec-tRNA synthase antibody; SepSecS antibody; SLA antibody; SLA p35 antibody; SLA-p35 antibody; SLA/LP antibody; SLA/LP autoantigen antibody; Soluble liver antigen antibody; Soluble liver antigen/liver pancreas antigen antibody; Soluble Liver/Pancreas Antigen antibody; SPCS_HUMAN antibody; tRNA(Ser/Sec) associated antigenic protein antibody; tRNA(Ser/Sec)-associated antigenic protein antibody; TRNP48 antibody; UGA suppressor tRNA associated protein antibody; UGA suppressor tRNA-associated protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SEPSECS
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
基因功能參考文獻：
1. Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase has been described. PMID: 27576344
2. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in SEPSECS. PMID: 28133863
3. The progression of clinical symptoms in these families is evidently slower than in previously reported cases, and the cerebellar atrophy milder by brain MRI, indicating that SEPSECS mutations are also involved in milder late-onset cerebellar atrophy. PMID: 26888482
4. results suggest SEPSECS as a candidate gene for progressive encephalopathies with lactate elevation. PMID: 26115735
5. structural analysis of the terminal catalytic complex in selenocysteine synthesis PMID: 25190812
6. Data suggest SEPSECS silencing in placental trophoblasts inhibits proliferation, induces apoptosis, and reduces production of progesterone/chorionic gonadotropin (P/hCG); SEPSECS over-expression promotes cell proliferation and secretion of P/hCG. PMID: 23966103
7. The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. PMID: 20623998
8. SepSecS mutations cause autosomal-recessive progressive cerebellocerebral atrophy in Jews of Iraqi and Moroccan ancestry. PMID: 20920667
9. detectable in liver extracts of autoimmune hepatitis patients' cells as the major autoantigenic component PMID: 19683415
10. crystal structure of tRNA(Sec) in complex with SepSecS, phosphoserine, and thiophosphate, together with in vivo and in vitro enzyme assays, supports a pyridoxal phosphate-dependent mechanism of Sec-tRNA(Sec) formation PMID: 19608919
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相關疾病：

Pontocerebellar hypoplasia 2D (PCH2D)
亞細胞定位：

Cytoplasm.
蛋白家族：

SepSecS family
組織特異性：

Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
數據庫鏈接：

HGNC: 30605

OMIM: 613009

KEGG: hsa:51091

STRING: 9606.ENSP00000371535

UniGene: Hs.253305

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