SEC23IP Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SEC23IP Polyclonal antibody
Uniprot No.：

Q9Y6Y8
基因名：

SEC23IP
別名：

MSTP053 antibody; p125 antibody; P125A antibody; Phospholipase antibody; S23IP_HUMAN antibody; Sec23 interacting protein p125 antibody; SEC23-interacting protein antibody; SEC23IP antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human SEC23-interacting protein (779-989AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).
基因功能參考文獻：
1. A basic cluster and a hydrophobic interface in the DDHD and SAM domains, respectively, are required for p125A-mediated functional endoplasmic reticulum exit site assembly. PMID: 24522181
2. Xenopus sec23ip is required for normal neural crest cell development, suggesting a role for the human ortholog in Waardenburg syndrome neural crest defects. PMID: 20308572
3. The results suggest that p125A is part of the Sec13/Sec31A subcomplex and facilitates ER export in mammalian cells. PMID: 20679433
4. p125 is a mammalian-specific component of ER exit sites and participates in the organization of this compartment PMID: 15623529
亞細胞定位：

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum.
蛋白家族：

PA-PLA1 family
組織特異性：

Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle.
數據庫鏈接：

HGNC: 17018

OMIM: 617852

KEGG: hsa:11196

STRING: 9606.ENSP00000358071

UniGene: Hs.435004

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