SCNN1B Antibody
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中文名稱：SCNN1B兔多克隆抗體
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貨號(hào)：CSB-PA040297
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：SCNN1B
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別名：Amiloride sensitive sodium channel subunit beta antibody; Amiloride-sensitive sodium channel subunit beta antibody; Beta NaCH antibody; Beta-ENaC antibody; Beta-NaCH antibody; ENaC beta antibody; ENaCB antibody; Epithelial Na(+) channel subunit beta antibody; Epithelial Na+ channel beta subunit antibody; Epithelial Na+ channel subunit beta antibody; Epithelial sodium channel beta 2 subunit antibody; Epithelial sodium channel beta 3 subunit antibody; Nonvoltage gated sodium channel 1 beta subunit antibody; Nonvoltage gated sodium channel 1 subunit beta antibody; Nonvoltage-gated sodium channel 1 subunit beta antibody; SCNEB antibody; SCNN 1B antibody; SCNN1B antibody; SCNNB_HUMAN antibody; Sodium channel nonvoltage gated 1 beta (Liddle syndrome) antibody; Sodium channel nonvoltage gated 1 beta antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human ENaC β around the non-phosphorylation site of T615.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
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基因功能參考文獻(xiàn)：
- No association was found between single nucleotide polymorphism rs12447134 of sodium channel, nonvoltage-gated 1, beta protein (SCNN1B) gene with the onset of disease hypertension. PMID: 29419876
- The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations PMID: 28708422
- hENaC incorporating the Liddle-mutated beta-subunit lacks one or more PKC phosphorylation sites, thereby significantly reducing the inhibitory effect of PKC on Na(+) channel activity, whereas hENaC incorporating Liddle-mutated gamma-subunits remains as susceptible to PKC as wild-type hENaC. PMID: 26759146
- deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP. PMID: 27941075
- Results identify SCNN1B as a tumor-suppressive function that triggers UPR in gastric cancer cells, with implications for its potential clinical applications as a survival biomarker in gastric cancer patients. PMID: 28202509
- These results indicated a significant association between EH and SCNN1B methylation, which was affected by age, gender and antihypertensive therapy. PMID: 27840946
- Three nonsynonymous amino acid variants in SCNN1B in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was PMID: 25900089
- These results do not suggest an important role for the T594M variant of the ENaC gene contributing to either the development or severity of hypertension in subjects of Indo-Aryan ancestry. PMID: 25173196
- causative mutation for Liddle's syndrome (LS) in this patient was identified to be a novel frameshift mutation. DNA sequencing resulted in exon 13 of SCNN1B gene: SCNN1B NM_000336.2:c.1 724_1730dupGGCCCAC [p.Pro5 75Argfs*17]. PMID: 26638596
- analysis of a novel frameshift mutation in the betaENaC gene in an isolated case of Liddle syndrome PMID: 25378078
- Suggest that SCNN1B gene has important roles in blood pressure regulation in the Han Chinese population. PMID: 25231509
- significant association between the rs3743966 SNP in intron 12 of epithelial sodium channel beta-subunit and essential hypertension PMID: 24888492
- Suggest that beta-ENaC mediates cytotrophoblast migration and increasing beta-ENaC expression by HO-1 induction enhances migration. PMID: 24553299
- ENaCbeta but not ENaCalpha expression is significantly lower in severe preeclampsia compared with normal pregnancy. PMID: 23977235
- The R563Q SCNN1beta variant is strongly associated with hypertension in urban areas in South Africa. PMID: 22895453
- study reports an adolescent with Liddle syndrome caused by a novel missense mutation, P614L, in the PY motif of the ENaC beta subunit. This missense mutation was found in 6 members of the adolescent's family as well PMID: 22809657
- analysis of eight extracellular domain residues in human beta- and gammaENaC that are required for regulation by acidic pH PMID: 23060445
- these data suggests that miR-16 upregulates ENaC, a major sodium channel involved in resolution of pulmonary edema in acute lung injury. PMID: 22940131
- Family study of hypertension caused by Liddle syndrome revealed a heterozygous mutation c.C1852T (p.Pro618Ser) in the SCNN1B gene. PMID: 21956615
- Breathing pattern is progressively altered in betaENaC-transgenic mice, likely reflecting airflow limitation due to airway mucus obstruction. PMID: 21700000
- variants of ENaC subunits A,B,G may contribute to the variation of BP response to dietary sodium intake PMID: 21562341
- The R563Q mutation of beta-ENaC is associated with hypertension within affected kindreds, but does not usually cause the full Liddle's syndrome phenotype. PMID: 21107496
- a SNP in SCNN1B was significantly associated with lower systolic and diastolic blood pressure in physically active Chinese. PMID: 21654856
- heterozygous C to T mutation at codon 617 in exon 13 of SCNN1B in the proband and in all of the members of the maternal lineage submitted to genetic analysis PMID: 21525970
- Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium. PMID: 19520916
- Genotypes of the betaENaC gene have little influence on blood pressure level in the Japanese population. PMID: 11863256
- cloned and characterized the 5' end of the human beta-ENaC gene and identified alternate promoters that determine basal expression of separate transcripts PMID: 11934701
- Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel beta-subunit gene. PMID: 12107247
- homozygous mutation in the promoter region of betaENaC leads to pseudohypoaldosteronism type I, the first description of a mutation in the regulatory regions of an ENaC subunit leading to a clinical phenotype PMID: 12204893
- Frameshift mutation of beta subunit caused by single cytosine insertion at codon 595, introducing new stop codon at 605 and deleting last 34 amino acids from normally encoded protein. PMID: 12473861
- R563Q, a new variant of the beta epithelial sodium channel, is associated with low-renin, low-aldosterone hypertension. Only a minority of individuals with the R563Q allelle fully express the Liddle's syndrome phenotype. PMID: 12714866
- No support for an important role for the T594M variant of the ENaC gene contributing to either the development or severity of hypertension in subjects of African ancestry. PMID: 14553964
- in ulcerative colitis, elevated proinflammatory cytokines selectively impair beta- and gamma-ENaC expression, which contributes to diarrhea by reducing colonic sodium absorption. PMID: 15188166
- The roles of these missense mutations in the SCNN1B or SCNN1G gene identified in hypertensive patients are not clear in the pathogenesis of hypertension and the regulation of electrolytes. PMID: 15198480
- Common variants of the ENaC beta subunit confer susceptibility to human essential hypertension. PMID: 15661075
- concluded that the T594M allele does not contribute significantly to blood pressure in blacks and does not predict a significantly superior response to amiloride therapy PMID: 16432044
- SCNN1B is a modulator in Cystic fibrosis. PMID: 16463024
- P616H mutation may be the underlying cause for the signs and symptoms of Liddle's syndrome. PMID: 16943574
- Concerted action of short chain fatty acids and corticosteroid hormones is required for induction of ENaC and maintenance of intestinal electrogenic sodium absorption PMID: 17241874
- both mouse and human mammary cells express all ENaC subunits, and they are regulated by steroid hormones in a temporal and cell-specific manner both in culture and in vivo PMID: 17510235
- genetic variants in ENaCbeta (epithelial sodium channel beta) genes do not modulate disease severity in the majority of CF patients PMID: 17560176
- We have identified a polymorphic GT short tandem repeat, which is present in the Chilean population. Biochemical analysis showed a possible linkage between this polymorphic region and low renin hypertension. PMID: 17586416
- We have shown a modest sized but highly significant effect of common genetic variation in the SCNN1B gene on plasma potassium PMID: 18184758
- A novel point mutation in epithelial sodium channel beta subunit, causing a substitution of a leucine residue for the second proline residue of the conserved PY motif (PPP x Y) of the beta subunit was identified in the proband PMID: 18398334
- Several variants in ENaCbeta and gamma genes might be deleterious for ENaC function and lead to bronchiectasis. PMID: 18507830
- SCNN1B is hypermethylated in renal cell carcinoma. PMID: 18639284
- Alpha-, beta- and gamma-ENaC messenger RNAs are detected in amiloride-sensitive BeWo trophoblast cells. PMID: 18665318
- A Thai family with Liddle's syndrome caused by a novel P615H missense mutation in the proline-rich domain of the SCNN1B gene coding for the beta-subunit of ENaC. PMID: 19344079
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相關(guān)疾病：Pseudohypoaldosteronism 1, autosomal recessive (PHA1B); Liddle syndrome (LIDLS); Bronchiectasis with or without elevated sweat chloride 1 (BESC1)
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亞細(xì)胞定位：Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
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蛋白家族：Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1B subfamily
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組織特異性：Detected in placenta, lung and kidney. Expressed in kidney (at protein level).
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