SARAF Antibody, FITC conjugated

說明書

中文名稱：

SARAF兔多克隆抗體, FITC偶聯
貨號：

CSB-PA853392HC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SARAF Polyclonal antibody
Uniprot No.：

Q96BY9
基因名：

SARAF
別名：

FLJ22274 antibody; FOAP 7 antibody; HBV X transactivated gene 3 protein antibody; HBV X-transactivated gene 3 protein antibody; HBV XAg-transactivated protein 3 antibody; HSPC035 antibody; MGC8721 antibody; Protein FOAP 7 antibody; Protein FOAP-7 antibody; TMEM 66 antibody; Tmem66 antibody; TMM66_HUMAN antibody; Transmembrane protein 66 antibody; XTP3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Store-operated calcium entry-associated regulatory factor protein (195-339AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
基因功能參考文獻：
1. SARAF also interacts with Orai1 and TRPC1 in cells endogenously expressing STIM1 and cells with a low STIM1 expression and modulates channel function. This review focuses on the modulation by SARAF of SOCE and other forms of Ca(2+) influx mediated by Orai1 and TRPC1 in order to provide spatio-temporally regulated Ca(2+) signals. PMID: 29223474
2. This activation was sensitive to Src kinase inhibition, but not to CAMKII nor PKC inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src-Raf-MEK-ERK, rather than upstream regulators. PMID: 28866365
3. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. PMID: 27414851
4. SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner PMID: 27506849
5. SARAF overexpression attenuated store operated Ca2+ entry and the STIM1-Orai1 interaction in cells endogenously expressing STIM1 and Orai1 while RNAi-mediated SARAF silencing induced opposite effects. PMID: 27068144
6. SARAF is constitutively expressed in the plasma membrane and interacts with Orai1. PMID: 26817842
7. Deletion of STIM1(448-490) and, in particular, STIM1(447-460) and STIM1(475-490) markedly enhances interaction of SARAF with STIM1. PMID: 23816623
8. Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PMID: 23049731
9. Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling by promoting a slow inactivation process of STIM2-dependent basal SOCE activity, as well as STIM1-mediated SOCE activity. PMID: 22464749
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亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
蛋白家族：

SARAF family
組織特異性：

Highly expressed in macrophages.
數據庫鏈接：

HGNC: 28789

OMIM: 614768

KEGG: hsa:51669

STRING: 9606.ENSP00000256255

UniGene: Hs.521487

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