SAR1B Antibody

說明書

中文名稱：

SAR1B兔多克隆抗體
貨號：

CSB-PA296125
規格：

￥2024
圖片：
Western blot analysis of extracts from LOVO cells and RAW264.7 cells, using SAR1B antibody.

Immunohistochemistry analysis of paraffin-embedded human placenta tissue using SAR1B antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SAR1B Polyclonal antibody
Uniprot No.：

Q9Y6B6
基因名：

SAR1B
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from internal of Human SAR1B.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
基因功能參考文獻：
1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
2. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
3. Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse. PMID: 28982670
4. SAR1B polymorphisms were associated with Alzheimer's disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening. PMID: 25703997
5. Our data also suggest that Sar1B overexpression contributes to regulation of CHOL transport and metabolism by facilitating rapid uptake and transport of CHOL. PMID: 25826777
6. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
7. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
8. Sar1b expression may promote intestinal lipid transport with the involvement of the coat protein complex II network and the processing of SREBP-1c. PMID: 21836065
9. Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene. PMID: 19846172
10. identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption PMID: 12692552
11. Sara2 is an important gene in processes involving erythroid cell proliferation and differentiation. PMID: 15943909
12. Five mutations in the SAR1B gene causing Anderson disease. PMID: 17945526
13. muscular as well as cardiac abnormalities that could be related to the reported expression of SARA2 in these tissues PMID: 18786134
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相關疾?。?/div>
Chylomicron retention disease (CMRD)
亞細胞定位：

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
蛋白家族：

Small GTPase superfamily, SAR1 family
組織特異性：

Expressed in many tissues including small intestine, liver, muscle and brain.
數據庫鏈接：

HGNC: 10535

OMIM: 246700

KEGG: hsa:51128

STRING: 9606.ENSP00000385432

UniGene: Hs.432984

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