RRAS2 Antibody

說明書

中文名稱：

RRAS2兔多克隆抗體
貨號(hào)：

CSB-PA020514ESR2HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: RRAS2 antibody at 2.66µg/ml
Lane 1: NIH/3T3 whole cell lysate
Lane 2: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 24, 16, 20, 25 kDa
Observed band size: 24 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA020514ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA020514ESR2HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) RRAS2 Polyclonal antibody
Uniprot No.：

P62070
基因名：

RRAS2
別名：

C86394 antibody; Oncogene RRAS2 antibody; Oncogene TC21 antibody; Ras like protein TC21 antibody; Ras related protein R Ras2 antibody; Ras-like protein TC21 antibody; Ras-related protein R-Ras2 antibody; Related RAS viral (r ras) oncogene homolog 2 antibody; Related RAS viral oncogene homolog 2 antibody; RRAS 2 antibody; RRAS2 antibody; RRAS2_HUMAN antibody; TC 21 antibody; TC21 antibody; Teratocarcinoma oncogene antibody; Teratocarcinoma oncogene TC21 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Ras-related protein R-Ras2 protein (1-204AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development.
基因功能參考文獻(xiàn)：
1. Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins. PMID: 27936046
2. R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma. PMID: 24826867
3. R-RAS2 is overexpressed in the early stages of malignancy in tumors of the human central nervous system. PMID: 24148564
4. This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors. PMID: 21781067
5. Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC. PMID: 20811707
6. RasGRF GEFs can activate TC21 in all sublocalizations except the Golgi complex. Farnesylated TC21 can be activated by RasGRF1 & RasGRF2, but geranylgeranylated TC21 is unresponsive to RasGRF2. PMID: 19692568
7. TGF-beta and TC21 have roles in tumorigenesis PMID: 17656362
8. TC21 directly links antigen receptors to PI(3)K-mediated survival pathways. PMID: 19561613
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相關(guān)疾病：

Ovarian cancer (OC)
亞細(xì)胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor.
蛋白家族：

Small GTPase superfamily, Ras family
組織特異性：

Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 17271

OMIM: 167000

KEGG: hsa:22800

STRING: 9606.ENSP00000256196

UniGene: Hs.502004

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