RPL10 Antibody

說明書

中文名稱：

RPL10兔多克隆抗體
貨號：

CSB-PA040237
規格：

￥1090
圖片：
Western Blot analysis of customer's (cat sample) using QM Polyclonal Antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P27635
基因名：

RPL10
別名：

RPL10 antibody; DXS648E antibody; QM antibody; 60S ribosomal protein L10 antibody; Laminin receptor homolog antibody; Large ribosomal subunit protein uL16 antibody; Protein QM antibody; Ribosomal protein L10 antibody; Tumor suppressor QM antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human QM.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
基因功能參考文獻：
1. The regulation of reactive oxygen species level by mitochondrial RPL10 is one of the major extra-ribosomal functions in pancreatic cancer cells, which could be used as an indicator for the tumorigenesis of pancreatic cancer. PMID: 30172100
2. there are 7 mutations in RPL10 in 344 patients, or a mutation frequency of 2% PMID: 28428269
3. A rare de novo mutation K78E is associated with severe syndromic intellectual disability and epilepsy. PMID: 29066376
4. Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells PMID: 27726420
5. Our results expand the mutational and clinical spectrum of RPL10 identifying a new genetic cause of SED and highlight the emerging role of ribosomal proteins in the pathogenesis of neurodevelopmental disorders. PMID: 26290468
6. report confirms the implication of RPL10 mutations in neurodevelopmental disorders and extends the associated clinical spectrum from autism to syndromic intellectual disability PMID: 25846674
7. A mutation within the conserved N-terminal end of RPL10, a protein in close proximity to the peptidyl transferase active site of the 60S ribosomal subunit, causes severe defects in brain formation and function. PMID: 25316788
8. Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias, with recurrent alterations of Arg98 in RPL10. PMID: 23263491
9. mutation analysis of RPL10 in German patients with autism spectrum disorder PMID: 21567917
10. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism PMID: 16940977
11. QM binds to c-yes at the SH3 domain in tumor cell lines PMID: 12138090
12. Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma PMID: 16331298
13. Xq28 (QM gene) may be involved in ovary failure. PMID: 17566674
14. A hexagonal crystal of L10CD was obtained by the sitting-drop vapour-diffusion method. The L10CD crystal diffracted to 2.5 A resolution and belongs to space group P3(1)21 or P3(2)21. PMID: 18007048
15. Characteristic interactions among Arg90-Trp171-Arg139 guide the C-terminal part outside of the central fold PMID: 18258260
16. Our results suggest that RPL10 has no major effect on the susceptibility to autism spectrum disorders PMID: 19166581
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相關疾病：

Autism, X-linked 5 (AUTSX5); Mental retardation, X-linked, syndromic, 35 (MRXS35)
蛋白家族：

Universal ribosomal protein uL16 family
數據庫鏈接：

HGNC: 10298

OMIM: 300847

KEGG: hsa:6134

STRING: 9606.ENSP00000341730

UniGene: Hs.534404

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