RNF212 Antibody

說明書

產品詳情

Uniprot No.：

Q495C1
基因名：

RNF212
別名：

FLJ38841 antibody; Hypothetical protein LOC285498 antibody; LOC285498 antibody; OTTHUMP00000147525 antibody; Probable E3 SUMO-protein ligase RNF212 antibody; RING finger protein 212 antibody; RN212_HUMAN antibody; RNF 212 antibody; RNF212 antibody; ZHP3 antibody; ZHP3; C. elegans; homolog of antibody; ZIP3-related protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human RNF212
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.
基因功能參考文獻：
1. The polymorphism of SNP rs4045481 in RNF212 gene might be associated with azoospermia and genotype CC of this SNP may be a risk factor of azoospermia. PMID: 29277047
2. This paper describes a partial transcript of the human RNF212 gene. PMID: 15340062
3. genome search identified sequence variants in the 4p16.3 region correlated with recombination rate in males & females; variants are located in the RNF212 gene, a putative ortholog of ZHP-3 gene essential for recombination & chiasma formation in C elegans PMID: 18239089
4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18239089
亞細胞定位：

Nucleus. Chromosome.
數據庫鏈接：

HGNC: 27729

OMIM: 612041

KEGG: hsa:285498

STRING: 9606.ENSP00000389709

UniGene: Hs.248290

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