RNF19A Antibody, Biotin conjugated
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中文名稱：RNF19A兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA868327LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) RNF19A Polyclonal antibody
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Uniprot No.：
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基因名：RNF19A
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別名：AA032313 antibody; DKFZP566B1346 antibody; Dorfin antibody; Double ring finger protein antibody; Double ring-finger protein antibody; E3 ubiquitin-protein ligase RNF19A antibody; p38 antibody; p38 protein antibody; Ring finger protein 19 antibody; RING finger protein 19A antibody; Ring IBR ring domain containing protein Dorfin antibody; RN19A_HUMAN antibody; RNF19 antibody; RNF19A antibody; Ubce7ip2 antibody; UIP117 antibody; XYbp antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human E3 ubiquitin-protein ligase RNF19A protein (741-825AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
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基因功能參考文獻(xiàn)：
- A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
- Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
- results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
- These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
- Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
- Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
- Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867
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亞細(xì)胞定位：Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
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蛋白家族：RBR family, RNF19 subfamily
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組織特異性：Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
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數(shù)據(jù)庫鏈接：
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