RHOB Antibody

說明書

中文名稱：

RHOB兔多克隆抗體
貨號：

CSB-PA916815
規格：

￥2024
圖片：
Western blot analysis of extracts from HepG2 cells and HeLa cells, using RHOB antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RHOB Polyclonal antibody
Uniprot No.：

P62745
基因名：

RHOB
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human RHOB.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
基因功能參考文獻：
1. vesicle-associated RhoB is a regulator of the Rab11-mediated recycling of LFA-1 to the cell surface, an event that is necessary for T lymphocyte motility. PMID: 29233918
2. These results suggest that miR-223-RhoB signaling pathway plays an important role in modulation of proliferation, cell arrest, and apoptosis in colon cancer. PMID: 29660302
3. data demonstrate the direct roles of miR-19a and miR-19b on the repression of RhoB and its consequences on tumorigenesis, cancer cell proliferation and invasiveness PMID: 29474434
4. Our study provides the first evidence that miR-223 can regulate pulmonary artery smooth muscle cells proliferation, migration, and actomyosin reorganization through its novel targets, RhoB and MLC2, resulting in vascular remodeling and the development of pulmonary arterial hypertension. PMID: 27121468
5. Vgamma9Vdelta2 TCR activation is modulated by the GTPase activity of RhoB and its redistribution to BTN3A1. PMID: 27210746
6. p53 isoform delta133p53ss regulates cancer cell apoptosis in a RhoB-dependent manner PMID: 28212429
7. RhoB may play a tumor suppressive role in clear cell renal cell carcinoma cells PMID: 27384222
8. These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB. PMID: 27832197
9. RhoB and ROCK play a key role in preeclampsia. PMID: 27324125
10. RhoB-specific regulation of Rac1 trafficking controls endothelial barrier integrity during inflammation. PMID: 27138256
11. The knockdown of RhoB protein decreased the proliferation rate of the parental and the IE1-expressing glioblastoma cells. PMID: 26741994
12. we propose that RhoB could be responsible for early metastatic prevention by inhibiting the EMT-derived invasiveness of lung cells through the control of PP2A activity. PMID: 26148238
13. Stimulating its ability to activate the antimetastatic small GTPase RhoB. PMID: 26759237
14. The isoprenylation and palmitoylation motif of human RhoB (-CINCCKVL) targets chimeric proteins to intraluminal vesicles of endolysosomes in human cells. PMID: 25207810
15. Findings highlight the degradation of RhoB via the neddylation-CRL pathway as an important molecular event that drives liver carcinogenesis. PMID: 25540389
16. Data suggest that RhoB belongs to an emerging class of "nononcogene addiction" factors that are essential for maintenance of malignant phenotypes in human cancers. PMID: 25216671
17. We showed that RhoB is not only a strong prognostic factor in NSCLC but it is also critical for the acquisition of an aggressive phenotype of adenocarcinoma. PMID: 25320360
18. RhoB depletion reduces cell-cell adhesion and downregulates E-cadherin levels as well as increasing internalized E-cadherin in DU145 prostate cancer cells. PMID: 25630770
19. Results support previous findings that vaiants in the RHOB and FAM167A-BLK genes may be associated with susceptibility to systemic sclerosis. PMID: 25470816
20. Suppressing RhoB levels by overexpressing Smurf1 or blocking Chk1-dependent Smurf1 self-degradation significantly inhibits apoptosis. PMID: 25249323
21. Taken together, our findings offer evidence that in human breast cancer RhoB acts as a positive function to promote expression of ERa and PR in a manner correlated with cell proliferation. PMID: 23339407
22. RHOB belongs to a novel class of "genes of recurrence" that have a dual role in metastasis and treatment resistance. PMID: 24321314
23. RhoB expression occurs frequently in ovary carcinogenesis and progression and its expression could be regulated by histone deacetylation but not by promoter hypermethylation. PMID: 24223801
24. RhoB controls TNFalpha signaling through the regulation of the TNFR traffic. PMID: 24086429
25. Overexpression of p300, PARP-1, or c-Jun dramatically enhanced RhoB promoter activity. PMID: 24636898
26. UVB-induced RhoB expression participates in in vivo squamous cell carcinoma initiation by increasing keratinocyte survival. PMID: 23792460
27. Data indicate that miR-21 induced the degradation of RhoB mRNA, which led to the depletion of RhoB and the impairment of tight junctions in intestinal epithelial cells. PMID: 23583411
28. RhoB contributes to directional cell migration by regulating beta1 integrin surface levels and activity, thereby stabilizing lamellipodial protrusions. PMID: 22724071
29. The variants in the RHOB gene were not associated with systemic sclerosis or any of its subsets. PMID: 22896740
30. Substitution of Val 43 with an Ile in RhoB negatively affected nucleotide exchange in vitro. PMID: 22673745
31. uPAR rapidly activated RhoB and increased RhoB expression. PMID: 22366462
32. RhoB may have a key role in ameloblastoma neoplastic epithelial cell phenotype determination, as well as in variant and subtype determination; different results of RhoB are observed in follicular and plexiform ameloblastomas. PMID: 22092654
33. AE downregulated mRNA expression and promoter/gelatinolytic activity of the RhoB expression at gene and protein level. PMID: 22227305
34. RhoB mediates adaptational changes to acute hypoxia in the vasculature, but its continual activation by chronic hypoxia can accentuate vascular remodeling to promote development of pulmonary hypertension. PMID: 22539766
35. miR-21 as a new angiogenesis inhibitor through repression of RhoB PMID: 21347332
36. Data show that expression of miR-21 in HEK293 and several colorectal cancer cell lines is inversely correlated with ras homolog gene family, member B (RhoB) expression. PMID: 21872591
37. A mechanism involving the nuclear GEFs Ect2 and Net1 for activating RhoB after genotoxic stress, thereby facilitating cell death after treatment with DNA damaging agents. PMID: 21373644
38. These results suggest that the activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 proteins to the distal CCAAT box of the RhoB promoter in Jurkat cells. PMID: 21565167
39. appears that RhoB plays an opposing role from that of RhoA and/or RhoC in gastric cancer cells. Our work suggests that RhoB may play a tumor suppressor role and subsequently may have potential implications in future targeted therapy PMID: 20473933
40. Up-regulation of RhoB significantly inhibited heat stress-induced apoptosis and elevated transcriptional activity of NF-kappaB. PMID: 20717930
41. suppressed RhoB is implicated as a molecular target for therapy against anaplastic thyroid carcinoma cells because RhoB is regulated and growth inhibited. PMID: 20810568
42. These findings suggest the involvement of RhoB in the process of spermatogenesis in humans PMID: 19997872
43. miR-21 promotes multiple components of the metastatic phenotype in vitro by regulating several important tumor suppressors, including RHOB. PMID: 20460403
44. we report, for the first time, the distribution of RhoB protein in the human scalp skin and hair follicles. PMID: 19889053
45. These results suggest that JNK contributes to RhoB induction, affecting the cell death response to gamma-radiation. PMID: 19995557
46. RhoB promotes cell motility and invasion in a metastatic prostate cancer cell. PMID: 19782069
47. Altogether, these results identify a mechanism by which RhoB antagonizes TGF-beta action through transcriptional down-regulation of AP1 in T beta R-II promoter. PMID: 11741970
48. RhoB is dispensable for normal cell physiology but it has a suppressor or negative modifier function in stress-associated processes including cancer. PMID: 11905808
49. Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. PMID: 13679859
50. RhoB expression is suppressed by EGFR, ErbB2 and Ras, but not Src. PMID: 14647415
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亞細胞定位：

Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
蛋白家族：

Small GTPase superfamily, Rho family
數據庫鏈接：

HGNC: 668

OMIM: 165370

KEGG: hsa:388

STRING: 9606.ENSP00000272233

UniGene: Hs.502876

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