RFX6 Antibody

中文名稱：

RFX6兔多克隆抗體
貨號：

CSB-PA812809LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA812809LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RFX6 Polyclonal antibody
Uniprot No.：

Q8HWS3
基因名：

RFX6
別名：

RFX6 antibody; RFXDC1 antibody; DNA-binding protein RFX6 antibody; Regulatory factor X 6 antibody; Regulatory factor X domain-containing protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA-binding protein RFX6 protein (1-260AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RFX6 Antibody (CSB-PA812809LA01HU)，的標記方式是Non-conjugated。對于RFX6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA812809LB01HU	RFX6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA812809LC01HU	RFX6 Antibody, FITC conjugated
Biotin	CSB-PA812809LD01HU	RFX6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.
基因功能參考文獻：
1. RFX6 heterozygous protein truncating variants cause reduced penetrance maturity-onset diabetes of the young (MODY). PMID: 29026101
2. study reports two individuals each with compound heterozygous RFX6 nonsense mutations and an intestinal phenotype consistent with Mitchell-Riley syndrome, but with onset of diabetes in childhood rather than in the first 2 weeks of life PMID: 26264437
3. association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. PMID: 26537068
4. RFX6 controls insulin gene transcription, insulin content, and secretion by regulation of Ca(2+)-channel genes. PMID: 25497100
5. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus. PMID: 23803082
6. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. PMID: 24390282
7. Our results provide further support for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in Eastern Asian populations PMID: 22662242
8. RFX6 mutation is responsible for neonatal diabetes syndrome. PMID: 21965172
9. Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the beta-cells in addition to their development. PMID: 21750414
10. In early development Rfx6 plays a broad role, being essential for development of most anterior endodermal organs. At later stages however, Rfx6 function is restricted to endocrine cells. PMID: 21215266
11. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20676098
12. studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans PMID: 20148032
13. RFX6 is a winged helix transcription factor expressed almost exclusively in the pancreatic islets. PMID: 18673564
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相關疾病：

Mitchell-Riley syndrome (MTCHRS)
亞細胞定位：

Nucleus.
蛋白家族：

RFX family
組織特異性：

Expressed in pancreas. Expressed in pancreatic beta-cells (insulin-positive cells) and alpha-cells (glucagon-positive cells) (at protein level). Specifically expressed in pancreas, small intestine and colon. Expressed in endocrine cells in the islets.
數據庫鏈接：

HGNC: 21478

OMIM: 612659

KEGG: hsa:222546

STRING: 9606.ENSP00000332208

UniGene: Hs.352276

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