RFX3 Antibody, Biotin conjugated

說明書

中文名稱：

RFX3兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA019612LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RFX3 Polyclonal antibody
Uniprot No.：

P48380
基因名：

RFX3
別名：

bA32F11.1 antibody; DNA binding protein RFX3 antibody; Regulatory factor X 3 antibody; Regulatory factor X; 3 (influences HLA class II expression) antibody; RFX3 antibody; RFX3_HUMAN antibody; Transcription factor RFX3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcription factor RFX3 protein (201-413AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.
基因功能參考文獻：
1. RFX3 interacts with the D sequence of adeno-associated virus inverted terminal repeat and regulates AAV transduction. PMID: 29317724
2. findings reveal a regulation of RFX3 transcription factor and link fatty acid metabolism and protein lipidation to the regulation of ciliogenesis. PMID: 30127002
3. FOXJ1 is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 as a transcriptional co-activator to FOXJ1. PMID: 23822649
4. RFX3 controls the expression of genes involved in primary ciliary dyskinesia. PMID: 19671664
亞細胞定位：

Nucleus.
蛋白家族：

RFX family
數據庫鏈接：

HGNC: 9984

OMIM: 601337

KEGG: hsa:5991

STRING: 9606.ENSP00000371434

UniGene: Hs.136829

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