REV3L Antibody
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中文名稱：REV3L兔多克隆抗體
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貨號：CSB-PA076411
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規(guī)格：￥2024
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圖片：
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DNA Polymerase ζ antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) REV3L Polyclonal antibody
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Uniprot No.：
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基因名：REV3L
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human DNA Polymerase ζ.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
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基因功能參考文獻：
- Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L PMID: 27849610
- These results demonstrate a previously unrecognized relationship between p53 and REV3L in cancer cell metabolism and may lead to improvements in chemotherapy treatment plans that reduce cisplatin resistance in lung cancer. PMID: 29307819
- REV3/ATR knockdown enhances the cytotoxicity of cisplatin in non-small cell lung cells. PMID: 28075014
- The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase. PMID: 27095204
- The results indicate that human DNA polymerase zeta plays important roles in induction of mutations, clastogenicity and in cellular survival of the damaged human cells. PMID: 27338670
- loss-of-function of REV3L dramatically enhanced the sensitivity of SCCHN cells to dacomitinib by the loss of both translesion synthesis and homologous recombination pathways. PMID: 26790612
- REV3L plays an important role in esophageal squamous cell carcinoma (ESCC) progression and chemoresistance, and is a potential diagnostic marker and therapeutic target for ESCC PMID: 26752104
- REV3 functions in mammalian mitochondria and that mitochondrial REV3 is associated with the tumorigenic potential of cells. PMID: 26462070
- Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment PMID: 26165320
- finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients PMID: 26068067
- data suggest that REV3L plays an important role in regulating cervical cancer cellular response to cisplatin PMID: 25781640
- Rev3, the catalytic subunit of polymerase zeta (Pol zeta), is involved in DNA replication under conditions of replication stress caused by deoxyribonucleotide shortage and/or imbalance in human lung adenocarcinoma cells. PMID: 25113059
- Single nucleotide polymorphisms in RBPJ, IL1R1, REV3L, TRAF3IP2, IRF1 and ICOS showed association with rheumatoid arthritis in black South Africans. PMID: 25014791
- Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatin-based chemotherapy PMID: 24956248
- Human Pol eta inserts a nucleotide opposite the lesion, followed by Pol zeta extending the DNA primer; thus, the two complement each other to fully bypass the cisplatin cross-link. PMID: 24449906
- DNA polymerase zeta is a predictor of poor prognosis for cervical cancer patients who are resistant to chemoradiation. PMID: 23456618
- A long-term depletion of Rev3 in cultured human cells results in massive genomic instability and severe cell cycle arrest. PMID: 23303771
- REV3L rs465646 variant modifies lung cancer susceptibility in Chinese Han population by affecting miRNA-mediated gene regulation PMID: 22349819
- analysis of the crystal structure of the ternary complex composed of the C-terminal domain of human REV1, REV7, and a REV3 fragment PMID: 22859296
- ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment has been crystallized. The crystals belonged to space group P3(1)21, with unit-cell parameters a = b = 74.7, c = 124.5 A PMID: 22869133
- our data suggest a significant role of genetic variation in the polymerase zeta subunit genes regarding the development and progression of BC. PMID: 21455670
- DNA polymerase zeta transgene participates directly in immunoglobulin hypermutation. PMID: 22547703
- REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus. PMID: 22303021
- The REV1/Polzeta complex maintains genomic stability by directly participating in DNA double-stranded break repair. PMID: 21926160
- Findings indicate that depletion of REV3 not only can amend cisplatin-based cancer therapy but also can be applied for susceptible cancers as a potential monotherapy. PMID: 22028621
- Data suggest that REV3 plays an important role in different cellular growth periods and physiological conditions. PMID: 20466635
- function of REV7 as an adapter protein to recruit Polzeta to a DNA lesion site PMID: 20164194
- show the first crystal structure of REV7 in complex with a fragment of REV3 polymerase (residues 1847-1898) and reveal the mechanism underlying REV7-REV3 interaction PMID: 20164194
- REV1 and Polzeta facilitate repair of interstrand cross-links independently of PCNA monoubiquitination and Poleta, whereas RAD18 plus Poleta, REV1, and Polzeta are all necessary for replicative bypass of cisplatin intrastrand DNA cross-links. PMID: 20028736
- To clarify the structural basis of the interaction between REV7 and REV3, REV7 was crystallized in complex with a REV3 fragment. PMID: 20054135
- REV3L Overexpression confers chemoresistance to cisplatin in gliomas. PMID: 19289490
- plays a critical role in the induction of mutations PMID: 12459444
- REV3 gene plays a role not only in lesion-targeted DNA mutagenesis, but also in mutagenesis on undamaged DNA templates that is called untargeted mutation. PMID: 12717825
- downregulation of rev3 might have occurred early during tumorigenesis. PMID: 18622427
- The study revealed that suppression of REV3 delayed spontaneous S phase progression and suppression of REV3 limits spontaneous and DNA damage induced mutagenesis. PMID: 18779149
- DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from xeroderma pigmentosum variant patients. PMID: 19564618
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亞細胞定位：Nucleus.
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蛋白家族：DNA polymerase type-B family
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組織特異性：Ubiquitously expressed.
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