RER1 Antibody

中文名稱：

RER1兔多克隆抗體
貨號：

CSB-PA019567LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA019567LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA019567LA01HU at dilution of 1:100

Immunofluorescent analysis of 293T cells using CSB-PA019567LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RER1 Polyclonal antibody
Uniprot No.：

O15258
基因名：

RER1
別名：

RER1; Protein RER1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein RER1 protein (85-139AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RER1 Antibody (CSB-PA019567LA01HU)，的標記方式是Non-conjugated。對于RER1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA019567LB01HU	RER1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019567LC01HU	RER1 Antibody, FITC conjugated
Biotin	CSB-PA019567LD01HU	RER1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
基因功能參考文獻：
1. RER1 is a novel and potential important mediator of elevated alphaSyn levels PMID: 28877262
2. Rer1p regulates the ER retention of immature or misfolded rhodopsin and modulates its intracellular trafficking through the early secretory pathway. PMID: 25096327
3. Charcot-Marie-Tooth disease-related PMP22 is trapped in the endoplasmic reticulum by calnexin-dependent retention and Rer1-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system. PMID: 25385046
4. Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression. PMID: 23479743
5. Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1, for degradation. PMID: 23129766
6. RER1 modulates amyloid-beta production by altering trafficking of gamma-secretase and amyloid precursor protein. PMID: 23043097
7. Downregulation of Rer1 leads to increased surface localization of Pen2, whereas overexpression of Rer1 stabilizes unassembled Pen2. Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals. PMID: 17668005
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亞細胞定位：

Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

RER1 family
數據庫鏈接：

HGNC: 30309

KEGG: hsa:11079

STRING: 9606.ENSP00000302088

UniGene: Hs.525527

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