RBSN Antibody, Biotin conjugated

說明書

中文名稱：

RBSN兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA884441LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RBSN Polyclonal antibody
Uniprot No.：

Q9H1K0
基因名：

RBSN
別名：

110 kDa protein antibody; FYVE finger containing Rab5 effector protein Rabenosyn 5 antibody; FYVE finger-containing Rab5 effector protein rabenosyn-5 antibody; Rabenosyn-5 antibody; RBNS5_HUMAN antibody; Zfyve20 antibody; zinc finger FYVE domain containing 20 antibody; Zinc finger FYVE domain-containing protein 20 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Rabenosyn-5 protein (201-500AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane.
基因功能參考文獻：
1. A functional defect in the endocytic pathway resulting from a point mutation in Rabenosyn-5 leads to severe multi-organ disorder. PMID: 25233840
2. transferrin receptors are delivered selectively from clathrin-coated pits on the plasma membrane into a specific subpopulation of endosomes enriched in the multivalent Rab GTPase and phosphoinositide-binding protein Rabenosyn-5. PMID: 22308388
3. Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244
4. results demonstrate that even the structurally similar effector domains in rabenosyn-5 can achieve highly selective recognition of distinct subsets of Rab GTPases exclusively through interactions with the switch and interswitch regions PMID: 16034420
亞細胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor.
數據庫鏈接：

HGNC: 20759

OMIM: 609511

KEGG: hsa:64145

STRING: 9606.ENSP00000253699

UniGene: Hs.475565

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