RBM45 Antibody, FITC conjugated

說明書

中文名稱：

RBM45兔多克隆抗體, FITC偶聯(lián)
貨號：

CSB-PA814203LC01HU
規(guī)格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RBM45 Polyclonal antibody
Uniprot No.：

Q8IUH3
基因名：

RBM45
別名：

Developmentally-regulated RNA-binding protein 1 antibody; DRB1 antibody; FLJ44612 antibody; MGC42237 antibody; Putative RNA binding protein RB 1 antibody; RB-1 antibody; RBM45 antibody; RBM45_HUMAN antibody; RNA-binding motif protein 45 antibody; RNA-binding protein 45 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human RNA-binding protein 45 protein (170-244AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.
基因功能參考文獻：
1. Results suggest that RBM45 serves as a negative regulator to prevent FUS-mediated excessive recruitment of HDAC1 to the sites of DNA damage. PMID: 29140459
2. Analysis of the biological processes and pathways associated with RBM45-interacting proteins indicates enrichment for nuclear RNA processing/splicing via association with hnRNP proteins and cytoplasmic RNA translation via eiF2 and eiF4 pathways. PMID: 26979993
3. using an in vitro cellular model, we demonstrated that Drb1 co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43 PMID: 27226551
4. RMB45 may function as a homo-oligomer and that its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation. PMID: 26391765
5. Data indicate that RNA binding protein RBM45/Kelch-like ECH-associated protein 1 (KEAP1) interactions in amyotrophic lateral sclerosis (ALS) spinal cord. PMID: 25939382
6. This study demonistrated that RBM45 protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. PMID: 22993125
7. a new member of RRM-type neural RNA-binding protein PMID: 12220514
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亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.
數(shù)據(jù)庫鏈接：

HGNC: 24468

OMIM: 608888

KEGG: hsa:129831

STRING: 9606.ENSP00000286070

UniGene: Hs.377257

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