RASA3 Antibody

說明書

中文名稱：

RASA3兔多克隆抗體
貨號：

CSB-PA169782
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA169782(RASA3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情

Uniprot No.：

Q14644
基因名：

RASA3
別名：

GAP III antibody; GAP1(IP4BP) antibody; GAP1IP4BP antibody; GAPIII antibody; GTPase activating protein 1 family antibody; GTPase activating protein III antibody; Inositol 1 3 4 5 tetrakisphosphate binding protein antibody; Inositol 1345 tetrakisphosphate binding protein antibody; Ins P4 binding protein antibody; Ins P4-binding protein antibody; Ins(1 3 4 5)P4 binding protein antibody; Ins(1345)P4 binding protein antibody; MGC46517 antibody; MGC47588 antibody; Ras GTPase activating protein 3 antibody; Ras GTPase-activating protein 3 antibody; RAS p21 protein activator 3 antibody; RASA 3 antibody; RASA3 antibody; RASA3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human RASA3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
基因功能參考文獻：
1. Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. PMID: 29381707
2. these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. PMID: 27903653
3. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. PMID: 25294679
4. role in intracellular calcium homeostasis PMID: 12356770
5. model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger PMID: 19433443
6. GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate. PMID: 7637787
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亞細胞定位：

Cell membrane.
數據庫鏈接：

HGNC: 20331

OMIM: 605182

KEGG: hsa:22821

STRING: 9606.ENSP00000335029

UniGene: Hs.593075

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