RARRES1 Antibody
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中文名稱(chēng)：RARRES1兔多克隆抗體
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貨號(hào)：CSB-PA843377
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA843377(RARRES1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA843377(RARRES1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 10+15%SDS-PAGE, Lysate: 50 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA843377(RARRES1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：RARRES1
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別名：RARRES1; PEIG1; TIG1; Retinoic acid receptor responder protein 1; Phorbol ester-induced gene 1 protein; PERG-1; RAR-responsive protein TIG1; Tazarotene-induced gene 1 protein
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human RARRES1
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:100-1:300 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
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基因功能參考文獻(xiàn)：
- TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. PMID: 29902837
- Data demonstrated that RARRES1 expression is lost in choriocarcinoma tumors due to promotor hypermethylation. Also, further results hypothesized that RARRES1 might be a negative regulator of EMT through induction of contact inhibition. PMID: 29169400
- Data show that retinoic acid receptor responder 1 (RARRES1) expression is subtype-dependent and regulated by DNA methylation and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3). PMID: 27286452
- Data suggest that Retinoic Acid Receptor Responder (RARRES1)/ Tazarotene-induced gene-1 (TIG-1) may serve as a target for therapeutic intervention both in cancer and in angiogenesis-related disorders. PMID: 28678839
- Authors found that transmembrane protein 192 (TMEM192) interacted with TIG1. Authors also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins. PMID: 27989102
- All-trans retinoic acid modulated secretion of RARRES1 in a dose dependent manner. PMID: 22942771
- our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in hepatocellular carcinoma . PMID: 24006221
- High TIG1 expression is associated with inflammatory breast cancer through activation of Axl kinase. PMID: 24014597
- Analysis of a standard liver fibrosis model (CCl(4)) demonstrated an early induction of RARRES1 mRNA and protein expression. PMID: 22669512
- genotype-associated hypermethylation of the ETS-family target gene RARRES1 influences methylation at its neighbor gene LXN and could be useful as a prognostic biomarker. PMID: 22573467
- Knocking-down CTCF expression hampered RARRES1 expression. PMID: 22615834
- TIG1 suppressed PGE2-stimulated Wnt and cAMP signaling pathways in colon cancer cells through GRK5. PMID: 22126303
- GRK5 mediates cell growth suppression by TIG1A. Thus, TIG1 may participate in the downregulation of G-protein coupled signaling by upregulating GRK5 expression. PMID: 21575264
- The results of this study suggested that short RAI1 alleles might be releated to schizophreina disease. PMID: 21168224
- RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis. PMID: 21303978
- Silencing of TIG1 promoter by hypermethylation is common in human cancers and may contribute to the loss of retinoic acid responsiveness in some neoplastic cells. PMID: 15059893
- Hypermethylation of tazarotene-induced gene 1 is associated with gastric carcinogenesis PMID: 16134180
- TIG1 overexpression in SASC inhibited their differentiation into osteocytes and the expression of osteocalcin PMID: 19250291
- Findings suggest that TIG1 may play a role in cellular proliferation and invasion in NPC cells and that its function may be dependent on the EBV status. PMID: 19737656
- TIG1 undergoes frequent epigenetic inactivation due to aberrant DNA hypermethylation in gastric cancers. PMID: 19806788
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亞細(xì)胞定位：Membrane; Single-pass type III membrane protein.
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蛋白家族：Protease inhibitor I47 (latexin) family
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