RAB3A Antibody, Biotin conjugated

說(shuō)明書(shū)

中文名稱(chēng)：

RAB3A兔多克隆抗體, Biotin偶聯(lián)
貨號(hào)：

CSB-PA019194LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) RAB3A Polyclonal antibody
Uniprot No.：

P20336
基因名：

RAB3A
別名：

Rab 3A antibody; RAB 3A member RAS oncogene family antibody; Rab3a antibody; RAB3A member RAS oncogene family antibody; RAB3A_HUMAN antibody; RAS associated protein RAB 3A antibody; RAS associated protein RAB3A antibody; Ras related protein Rab 3A antibody; Ras related protein Rab3A antibody; Ras-related protein Rab-3A antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Ras-related protein Rab-3A protein (1-220AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction.
基因功能參考文獻(xiàn)：
1. Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
2. Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. PMID: 24965146
3. Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein. PMID: 25713146
4. Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified PMID: 24652202
5. alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity PMID: 23344955
6. Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. PMID: 22753498
7. Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
8. a possible role in glomerulopathies PMID: 12937130
9. Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. PMID: 15005721
10. Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association. PMID: 16099449
11. In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population. PMID: 16584842
12. Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP). PMID: 17625073
13. Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes PMID: 18559336
14. Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis PMID: 19546222
15. The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity. PMID: 19923287
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亞細(xì)胞定位：

Cytoplasm, cytosol. Lysosome. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell membrane; Lipid-anchor; Cytoplasmic side.
蛋白家族：

Small GTPase superfamily, Rab family
組織特異性：

Specifically expressed in brain.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 9777

OMIM: 179490

KEGG: hsa:5864

STRING: 9606.ENSP00000222256

UniGene: Hs.27744

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