Pla2g2a Antibody

^{Rare Species}

中文名稱：

Pla2g2a兔多克隆抗體
貨號：

CSB-PA321246LA01RA
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Pla2g2a Polyclonal antibody
Uniprot No.：

P14423
基因名：

Pla2g2a
別名：

Pla2g2a antibody; Phospholipase A2 antibody; membrane associated antibody; EC 3.1.1.4 antibody; GIIC sPLA2 antibody; Group IIA phospholipase A2 antibody; Phosphatidylcholine 2-acylhydrolase 2A antibody
宿主：

Rabbit
反應種屬：

Rat
免疫原：

Recombinant Rat Phospholipase A2, membrane associated protein (22-146AA)
免疫原種屬：

Rattus norvegicus (Rat)

標記方式：

Non-conjugated

本頁面中的產品，Pla2g2a Antibody (CSB-PA321246LA01RA)，的標記方式是Non-conjugated。對于Pla2g2a Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA321246LB01RA	Pla2g2a Antibody, HRP conjugated	ELISA
FITC	CSB-PA321246LC01RA	Pla2g2a Antibody, FITC conjugated
Biotin	CSB-PA321246LD01RA	Pla2g2a Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response. Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner.
基因功能參考文獻：
1. The present study was designed to determine the relationship between phenformin coupling AMP-activated protein kinase (AMPK) function and the molecular mechanism by which the sPLA2 IIA expression was modulated in vascular smooth muscle cells. PMID: 26162096
2. a novel inverse recruitment mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression. PMID: 23629656
3. Secreted PLA2-IIA regulates the permeability of microvascular endothelial cells during brain inflammation. PMID: 22788969
4. Data show changes in cell morphology and upregulation of ERK1/2, iNOS and sPLA-IIA expression in astrocytes and microglia on exposure to lipopolysaccharides and cytokines. PMID: 21943492
5. cPLA(2)alpha-mediated induction of PPAR-beta/delta is a novel intracellular signalling pathway in spontaneous and TGF-beta induced activation of hepatic stellate cells. PMID: 22093332
6. The expression of sPLA(2)-IIA in the dorsal horn and spinal trigeminal nucleus is consistent with previous results which showed an important role of CNS sPLA(2) in nociceptive transmission. PMID: 20153419
7. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals PMID: 20086008
8. During atherogenesis, SAA can amplify the involvement of smooth muscle cells in vascular inflammation and that this can lead to deposition of sPLA(2) and subsequent local changes in lipid homeostasis. PMID: 19850938
9. A calcium-independent, type IIA secretory phospholipase A2 newly isolated from liver mitochondria, most apparent in media of high ionic strength, initiates the removal of poorly functioning mitochondria by processes involving autolysis. PMID: 12056909
10. sPLA(2) may modulate neuronal COX-2 expression through mechanisms that differ from those of glutamate-induced COX-2 expression PMID: 12111798
11. analysed the activation of sPLA(2) transcription by cAMP and interleukin-1beta and showed that the 500 bp region upstream of the transcription start site of the sPLA(2) gene is implicated in activation by synergistically acting cAMP and IL-1beta PMID: 12188923
12. tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression is potentiated in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation PMID: 12782627
13. Transcriptional activation of the group IIA secretory phospholipase A2 gene in vascular smooth muscle. PMID: 12882648
14. in a neonatal model, the development of an acidic surface pH can be ascribed, in part, to progressive stratum corneum acidification by two endogenous mechanisms, namely, sPLA2 and NHE1 PMID: 15009712
15. We investigated temporal and spatial expression of sPLA2-IIA mRNA and immunoreactivity in transient focal cerebral ischemia, demonstrating an up-regulation of the inflammatory sPLA2-IIA in reactive astrocytes in response to cerebral ischemia-reperfusion. PMID: 15255941
16. new autocrine and paracrine pathways activating sPLA2-IIA gene expression in rat and human vascular smooth muscle cells PMID: 15802623
17. 12/15-LOX-dependent up-regulation of sPLA2-IIA expression may result from the interplay between accelerated MIP-2 signaling, AP-1 activation, and attenuated transforming growth factor-beta and platelet-derived growth factor signaling PMID: 15878884
18. the neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2A PMID: 15927955
19. These results indicate that phospholipase A(2)-IIA is coexpressed with SNAP-25 in mature taste receptor cells that possess exocytotic machinery. PMID: 16385482
20. cytosolic and group IIA secreted phospholipases A(2) work together to liberate arachidonate from phospholipids in response to cytokines PMID: 16603549
21. HMGB1 slightly activated the sPLA2-IIA, COX-2, and mPGES-1 genes but dramatically stimulated these genes in VSMCs that had been incubated with the proinflammatory cytokine IL-1beta PMID: 16807371
22. It was shown that exposure of cultured astrocytes to oxygen glucose deprivation (0.5-24h) causes an increase in cPLA(2) and sPLA(2) expression and activity. PMID: 17462919
23. a novel regulatory role of iPLA(2)gamma in stimulus-coupled sPLA(2)-IIA expression. PMID: 17475622
24. On Chr 5, Pla2g2a is subject to a syntenic control while expression of the Tp53 (Chr 10) and Pmai1/Noxa (Chr 18) genes appears to be controlled by several mammary cancer resistance QTLs. PMID: 19052818
25. Simvastatin may reduce the process of atherosclerosis by decreasing the expression level of sPLA2 IIa in myocardium and aorta. PMID: 19237014
26. sPLA(2)-IIA may be an important mediator of oligodendrocyte death and a novel target for therapeutic intervention following spinal cord injury PMID: 19306380
27. Reactive oxygen species from NADPH oxidase iare involved in cytokine induction of sPLA2-IIA in astrocytes. Botanical antioxidants may be protective agents for inhibition of inflammatory responses in these cells. PMID: 19375465
28. sPLA2-derived oxidative products contribute to significant neurovascular damage, and treatment with sPLA2 inhibitor DEDA ameliorates secondary injury by reducing exacerbations from lipoxidative stress. PMID: 19678934
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亞細胞定位：

Secreted. Cell membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein.
蛋白家族：

Phospholipase A2 family
數據庫鏈接：

KEGG: rno:29692

STRING: 10116.ENSRNOP00000022827

UniGene: Rn.11346

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