Phospho-HIST1H1D (T146) Antibody

說明書

中文名稱：

磷酸化-HIST1H1D (T146)兔多克隆抗體
貨號：

CSB-PA010379OA146phHU
規格：

￥440
圖片：
Immunocytochemistry analysis of CSB-PA010379OA146phHU diluted at 1:10 and staining in Hela cells(treated with 50nM Calyculin A for 30min) performed on a Leica BondTM system. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HIST1H1D Polyclonal antibody
Uniprot No.：

P16402
基因名：

HIST1H1D
別名：

Histone H1.3 (Histone H1c) (Histone H1s-2), HIST1H1D, H1F3
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from Human Histone H1.3 protein (137-149aa)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, ICC

推薦稀釋比：

Application	Recommended Dilution
ICC	1:10-1:100

Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
基因功能參考文獻：
1. Results show that histone H1.3, was identified only in non-neoplastic MCF-10A breast cells but not in metastatic MDA-MB-231 breast cancer cells . PMID: 26209608
2. Histone H1 organizes and maintains an extensive protein-protein interaction network in the nucleolus required for nucleolar structure and integrity. PMID: 25584861
3. overexpression of histone cluster 1 is associated with recurrence in meningiomas. PMID: 20685720
亞細胞定位：

Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
蛋白家族：

Histone H1/H5 family
數據庫鏈接：

HGNC: 4717

OMIM: 142210

KEGG: hsa:3007

STRING: 9606.ENSP00000244534

UniGene: Hs.136857

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