Phospho-ELK3 (S357) Antibody
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中文名稱：磷酸化-ELK3 (S357)兔多克隆抗體
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貨號：CSB-PA008025
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規格：￥1090
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圖片：
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Western Blot analysis of COLO cells using Phospho-Net (S357) Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：ELK3 antibody; ELK3; ETS domain protein (SRF accessory protein 2) antibody; ELK3_HUMAN antibody; ERP antibody; ETS domain protein antibody; ETS domain-containing protein Elk-3 antibody; ETS related protein ERP antibody; ETS related protein NET antibody; ETS-related protein ERP antibody; ETS-related protein NET antibody; NET antibody; SAP 2 antibody; SAP-2 antibody; SAP2 antibody; Serum response factor accessory protein 2 antibody; SRF accessory protein 2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Monkey
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免疫原：Synthesized peptide derived from Human Net around the phosphorylation site of S357.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
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基因功能參考文獻：
- Decreased Net expression characterize on-small-cell lung cancer progression. PMID: 19483189
- Net might play an important role in pancreatic carcinogenesis PMID: 23469073
- These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID: 27556500
- The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID: 27538444
- We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID: 27301639
- Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID: 28188790
- High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID: 27959451
- results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID: 26637400
- The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID: 25401928
- ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID: 24719561
- Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID: 20427288
- the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589
- These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID: 18832796
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亞細胞定位：Nucleus.
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蛋白家族：ETS family
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數據庫鏈接：
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