PYCR2 Antibody, HRP conjugated

說明書

中文名稱：

PYCR2兔多克隆抗體, HRP偶聯
貨號：

CSB-PA822188LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PYCR2 Polyclonal antibody
Uniprot No.：

Q96C36
基因名：

PYCR2
別名：

1810018M05Rik antibody; FLJ54750 antibody; Leftb antibody; OTTHUMP00000035614 antibody; P5C reductase 2 antibody; P5CR 2 antibody; P5CR2 antibody; P5CR2_HUMAN antibody; PYCR 2 antibody; PYCR2 antibody; Pyrroline 5 carboxylate reductase 2 antibody; Pyrroline 5 carboxylate reductase family member 2 antibody; Pyrroline 5 carboxylate reductase isoform antibody; Pyrroline-5-carboxylate reductase 2 antibody; RP4-559A3.4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Pyrroline-5-carboxylate reductase 2 protein (2-320AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Involved in cellular response to oxidative stress.
基因功能參考文獻：
1. PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction. PMID: 27130255
2. It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1. PMID: 26634742
3. Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. PMID: 26733354
4. Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development. PMID: 25865492
相關疾病：

Leukodystrophy, hypomyelinating, 10 (HLD10)
亞細胞定位：

Cytoplasm. Mitochondrion.
蛋白家族：

Pyrroline-5-carboxylate reductase family
組織特異性：

Detected in erythrocytes (at protein level). Expressed in fetal brain.
數據庫鏈接：

HGNC: 30262

OMIM: 616406

KEGG: hsa:29920

STRING: 9606.ENSP00000342502

UniGene: Hs.654718

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