PVRL2 Antibody

說明書

中文名稱：

PVRL2兔多克隆抗體
貨號：

CSB-PA019096GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q92692
基因名：

NECTIN2
別名：

CD 112 antibody; CD112 antibody; CD112 antigen antibody; Herpes virus entry mediator B antibody; Herpes virus entry protein B antibody; Herpesvirus entry mediator B antibody; Herpesvirus entry protein B antibody; Hve B antibody; HveB antibody; Nectin-2 antibody; Nectin2 antibody; Poliovirus receptor like 2 antibody; Poliovirus receptor related 2 (herpesvirus entry mediator B) antibody; Poliovirus receptor related 2 antibody; Poliovirus receptor related protein 2 antibody; Poliovirus receptor-related protein 2 antibody; PRR 2 antibody; PRR2 antibody; PVRL 2 antibody; PVRL2 antibody; PVRL2_HUMAN antibody; PVRR 2 antibody; PVRR2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Human PVRL2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.; (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
基因功能參考文獻：
1. Nectin-2 mutation in men with severe teratospermia PMID: 28689229
2. In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig. PMID: 28671524
3. Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT. PMID: 27978489
4. Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
5. energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated. PMID: 28515320
6. PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes. PMID: 28062492
7. Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients. PMID: 26184725
8. Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection. PMID: 26982466
9. PVRL2, TOMM40 and APOE might be associated with human longevity. PMID: 24924924
10. Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
11. Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA)-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system. PMID: 23465821
12. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion. PMID: 22927415
13. a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate PMID: 20662561
14. The CD112 is highly expressed in colon carcinoma tissues and cell lines. PMID: 20617580
15. The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection. PMID: 20410314
16. differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor Nectin-2 PMID: 12915581
17. There is an allelic association of sequence variation in PVRL2 and the severity of multiple sclerosis. PMID: 16738668
18. CD226/CD112 (DNAM-1/Nectin-2) mast cell stimulation has a role in the allergic process PMID: 16831868
19. identified PVRL2 as a new recurrent partner gene of the TRA@ locus in peripheral T-cell lymphoma PMID: 17696193
20. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2 are reported. PMID: 19478445
21. Regions of nectin-2 protein important for herpesvirus entry activity and homotypic nectin-nectin interactions are overlapping but not identical. PMID: 12438620
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Nectin family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 9707

OMIM: 600798

KEGG: hsa:5819

STRING: 9606.ENSP00000252483

UniGene: Hs.655455

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